| Project/Area Number |
24593127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
HARA Yoshitaka 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Atsutoshi 長崎大学, 大学院医歯薬学総合研究科(歯学系), 准教授 (70253680)
UKAI Takashi 長崎大学, 病院(歯学系), 講師 (20295091)
KANEKO Takashi 福岡歯科大学, 歯学部, 教授 (10284697)
YOSHINAGA Yasunori 福岡歯科大学, 歯学部, 准教授 (60452869)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インプラント周囲炎 / 歯周炎 / 免疫複合体 / 骨吸収 / LPS / ラット / 病理組織学的研究 / インプラント / 実験病理学的研究 / 歯周ポケット / A. actinomycetemcomitans / S. aureus / 免疫組織学的研究 |
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| Outline of Final Research Achievements |
We applied our experimental periodontitis model to the peri-implant tissues and compared periimplant destruction to periodontitis without using a ligature.
Rats were divided into five groups. Implantation was performed after extraction of right first molars in rats. The left first molars were left untreated to be examined as natural teeth. The immunized group consisted of rats that had received intraperitoneal LPS, whereas the non immunized group received only PBS. The untreated baseline group received only implantation. After booster injection, half of each group received topical application of LPS in the palatal gingival sulcus daily for 3 days. The other half of the groups received PBS. Histopathological and histometrical findings were observed. Peri-implant tissue destruction was greater in the immunized and LPS-applied groups than in the other groups. No periodontal destruction was observed. Antigen-induced peri-implant tissue destruction occurs faster than periodontal tissue
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