| Project/Area Number |
24593134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
MITANI Akio 愛知学院大学, 歯学部, 教授 (50329611)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Takeshi 愛知学院大学, 歯学部, 講師 (40421242)
AINO Makoto 愛知学院大学, 歯学部, 助教 (20572811)
ISHIHARA Yuichi 松本歯科大学, 歯学部, 教授 (50261011)
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| Research Collaborator |
FUJIMURA Takeki 愛知学院大学, 歯学部, 助教 (40749892)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | IL-35 / 歯周組織 / Th17 / 歯学 / 免疫学 / IL-17 / 歯周炎 |
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| Outline of Final Research Achievements |
IL-17- and IL-35-related gene expressions in gingiva and that protein levels in GCF were higher in patients with chronic periodontitis compared to the healthy group. There was a tendency toward a negative correlation between IL-17 and IL-35 in GCF samples; however, this was not significant. Furthermore, rIL-35 inhibited the Th17-related genes expression and IL-17 protein production in Th17 cells. These results suggest that IL-35 may directly act to the Th17 cells, and followed by inhibition of the IL-17 production.
Taken together, IL-35 might play a suppressive role in periodontal disease by inhibition of IL-17 production from Th17 cells in order to suppress excessive inflammation in gingiva.
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