| Project/Area Number |
24593137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University (2014)
Aichi Gakuin University (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Toshihide 愛知学院大学, 歯学部, 教授 (50014262)
MITANI Akio 愛知学院大学, 歯学部, 教授 (50329611)
OZAWA Yusuke 愛知学院大学, 歯学部, 非常勤助教 (50624326)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | インターロイキンー１ / インターロイキンー１レセプターアンタゴニスト / 遺伝子改変マウス / 実験的歯周炎 / 炎症性骨吸収 / サイトカイン / 歯周治療薬 / インターロイキンー１Ra / 遺伝子欠損マウス / 骨吸収因子 / IL-1 / IL-1Ra / A. actinomycetemcomitans / TNF-α / IL-6 / 骨関連遺伝子 / 破骨細胞 / 骨芽細胞 / 接着分子 / RNA干渉 |
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| Outline of Final Research Achievements |
The interleukin (IL)-1 receptor antagonist (Ra) binds to IL-1 receptors and inhibits IL-1 activity. However, it is unclear whether IL-1Ra plays a protective role in periodontal disease. This study was undertaken to compare experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in IL-1Ra knockout (KO) mice vs wild type (WT) mice. Computed tomography (CT) analysis, and hematoxylin eosin (H&E) and tartrate resistant acid phosphatase (TRAP) staining were performed.Infected IL-1Ra KO mice exhibited bone loss in furcation areas and alveolar fenestrations.
Considering from the all results, IL-1Ra inflammatory bone resorption in experimental periodontitis induced by A. actinomycetemcomitans down-osteoclast differentiation and up-osteoblast differentiation and calcification. In short, these data suggest that an IL-1Ra may serve as a potential therapeutic drug for periodontal disease.
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