The influence by which the interaction with Adipokine and periodontitis gives to vascular endothelial cell and hepatocyte
| Project/Area Number |
24593158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
FURUGEN Reiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (90253674)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Toshiyuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515)
HAYASHIDA Hideaki 長崎大学, 病院(歯学系), 講師 (20238140)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周病 / アディポカイン / 炎症 |
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| Outline of Final Research Achievements |
Pentraxin3 is one of the elements which participate in progress of atherosclerosis is produced directly from vascular endothelial cell and macrophage by an inflammatory stimulus. It was considered that periodontal inflammation could influenced on atherosclerosis, beacause of PTX3 production by pg-LPS stimutation in human monocytic cells. In addition to pg-LPS challenge, hyperglycemia have an effect on the expression of pentraxin3. It suggested that periodontal inflammation may affect systemic disease.
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Report
(4 results)
Research Products
(2 results)
