The influence by which the interaction with Adipokine and periodontitis gives to vascular endothelial cell and hepatocyte

• Project/Area Number: 24593158
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Nagasaki University
• Principal Investigator: FURUGEN Reiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (90253674)
• Co-Investigator(Kenkyū-buntansha): SAITO Toshiyuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515) ; HAYASHIDA Hideaki 長崎大学, 病院(歯学系), 講師 (20238140)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 歯周病 / アディポカイン / 炎症

Outline of Final Research Achievements

Pentraxin3 is one of the elements which participate in progress of atherosclerosis is produced directly from vascular endothelial cell and macrophage by an inflammatory stimulus. It was considered that periodontal inflammation could influenced on atherosclerosis, beacause of PTX3 production by pg-LPS stimutation in human monocytic cells. In addition to pg-LPS challenge, hyperglycemia have an effect on the expression of pentraxin3. It suggested that periodontal inflammation may affect systemic disease.

Research Products

• [Presentation] Porphyromonas gingivalis LPS刺激によるヒト単球系細胞におけるPentraxin3産生について (2014)
  • Author(s): 古堅麗子、林田秀明、斎藤俊行
  • Organizer: 第63回日本口腔衛生学会・総会
  • Place of Presentation: 熊本市民会館崇城大学ホール（熊本市）
  • Year and Date: 2014-05-29 – 2014-05-31
• [Presentation] Resistin release by lipopolysaccharides from Porphyromonas gingivalis via JNK and MAP kinase pathways (2012)
  • Author(s): Furugen R, Hayashida H, Saito T
  • Organizer: First International Conference on porphyromonas gingivalis and related bacterial species
  • Place of Presentation: Nagasaki University