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The influence by which the interaction with Adipokine and periodontitis gives to vascular endothelial cell and hepatocyte

Research Project

Project/Area Number 24593158
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionNagasaki University

Principal Investigator

FURUGEN Reiko  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (90253674)

Co-Investigator(Kenkyū-buntansha) SAITO Toshiyuki  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515)
HAYASHIDA Hideaki  長崎大学, 病院(歯学系), 講師 (20238140)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords歯周病 / アディポカイン / 炎症
Outline of Final Research Achievements

Pentraxin3 is one of the elements which participate in progress of atherosclerosis is produced directly from vascular endothelial cell and macrophage by an inflammatory stimulus. It was considered that periodontal inflammation could influenced on atherosclerosis, beacause of PTX3 production by pg-LPS stimutation in human monocytic cells. In addition to pg-LPS challenge, hyperglycemia have an effect on the expression of pentraxin3. It suggested that periodontal inflammation may affect systemic disease.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 2012

All Presentation (2 results)

  • [Presentation] Porphyromonas gingivalis LPS刺激によるヒト単球系細胞におけるPentraxin3産生について2014

    • Author(s)
      古堅麗子、林田秀明、斎藤俊行
    • Organizer
      第63回日本口腔衛生学会・総会
    • Place of Presentation
      熊本市民会館崇城大学ホール(熊本市)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Resistin release by lipopolysaccharides from Porphyromonas gingivalis via JNK and MAP kinase pathways2012

    • Author(s)
      Furugen R, Hayashida H, Saito T
    • Organizer
      First International Conference on porphyromonas gingivalis and related bacterial species
    • Place of Presentation
      Nagasaki University
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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