| Project/Area Number |
24593159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHITOMI Izumi 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (90363457)
UMEDA Masahiro 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60301280)
SAITOU Toshiyuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 頭頸部癌 / 放射線治療 / 口腔粘膜炎 / 口腔管理 / 頭頚部がん / 口腔ケア / 頭頸部がん |
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| Outline of Final Research Achievements |
Objective: In order to prevent and treat radiation-induced adverse events, especially oral mucositis, in patients with oral or oropharyngeal cancer receiving radiotherapy or chemoradiotherapy, a prophylactic bundle, i.e., a set of oral care management procedures, is conducted and assessed. Subjects and methods: The subjects were 30 patients with squamous cell carcinoma of the oral cavity or oropharynx who underwent radiotherapy. The patients received the prophylactic bundle to prevent radiation-induced oral mucositis during radiotherapy. Results: Severe oral mucositis, grade 3, was observed in 5 of 30 patients (17%). The occurrence of oral mucositis was lower than in previous reports. Conclusions: This preliminary study suggests that the prophylactic bundle, when performed in oral or oropharyngeal cancer patients, decreases severe radiation-induced oral mucositis. Further evaluation is needed in multi-centre, prospective, randomized trials.
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