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Toward the application of MK 615 to dental medicine:Analysis of anti-caries · anti-periodontal disease characteristics

Research Project

Project/Area Number 24593161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKagoshima University

Principal Investigator

Morimoto Yoko  鹿児島大学, 医歯学域附属病院, 助教 (30437967)

Co-Investigator(Kenkyū-buntansha) 川原 幸一  大阪工業大学, 工学部, 教授 (10381170)
徳田 雅行  鹿児島大学, 医歯学域歯学系, 准教授 (20253891)
菊池 清志  久留米大学, 医学部, 助教 (60404539)
鳥居 光男  鹿児島大学, 医歯(薬)学総合研究科, 教授 (30116066)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsMK615 / 抗炎症 / 抗菌 / 骨破壊抑制 / 破骨細胞 / mRNA / 歯肉線維芽細胞 / LPS / 歯学 / 抗う蝕
Outline of Final Research Achievements

This study examined whether plum meat extract, which is known to contribute to health promotion since ancient times, is effective for dental caries and periodontal disease treatment and prevention. Inflammatory cytokines produced from gingival tissue cells stimulated with LPS in the periodontal pathogenic bacteria has been shown to be significantly suppressed by the addition of plum extract MK615. In addition, MK 615 was shown to suppress bone destruction due to periodontal disease by suppressing the maturation of osteoclasts. Furthermore, it was shown that proliferation of dental caries-related bacteria and periodontal pathogenic bacteria can be suppressed significantly by adding MK615. From these facts, it was suggested that Plum Meat Extract Extract MK 615 is effective for anti-caries and anti-periodontal disease.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Japanese Apricot (Ume): Potential Oral Health Benefits2016

    • Author(s)
      Yoko Morimoto-Yamashita, Masayuki Tokuda, Yoshihiro Nishitani
    • Journal Title

      Apricots and Peaches: Nutritional Properties, Post-Harvest Management and Potential Health Benefits.

      Volume: 1 Pages: 9-24

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A natural therapeutic approach for the treatment of periodontitis by MK615.2015

    • Author(s)
      Yoko Morimoto-Yamashita, Yoshiko Kawakami, Syoko Tatsuyama, Keiko Miyashita, Makiko Emoto, Kiyoshi Kikuchi, Ko-ichi Kawahara, Masayuki Tokuda
    • Journal Title

      Medical Hypotheses

      Volume: 85 Issue: 5 Pages: 618-621

    • DOI

      10.1016/j.mehy.2015.07.028

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dentin and pulp sense cold stimulus.2015

    • Author(s)
      Tokuda M, Tatsuyama S, Fujisawa M, Morimoto-Yamashita Y, Kawakami Y, Shibukawa Y, Torii M.
    • Journal Title

      Medical Hypotheses

      Volume: 84 Issue: 5 Pages: 442-444

    • DOI

      10.1016/j.mehy.2015.01.039

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of TRPV1 and AQP2 in hypertonic stress by xylitol in odontoblast cells.2015

    • Author(s)
      35.Tokuda M*, Fujisawa M, Kawakami Y, Morimoto-Yamashita Y, Torii M
    • Journal Title

      Connect Tissue Res.

      Volume: 56 Issue: 1 Pages: 44-49

    • DOI

      10.3109/03008207.2014.984804

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Subcutaneous Emphysema Caused by Sodium Hypochlorite plus RC-Prep2014

    • Author(s)
      Masayuki Tokuda, Yoshiko Kawakami, Yoko Morimoto-Yamashita, Mitsuo Torii
    • Journal Title

      Open Journal of Stomatology

      Volume: 4 Issue: 12 Pages: 523-532

    • DOI

      10.4236/ojst.2014.412070

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke.2013

    • Author(s)
      Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, Maruyama I, Murai Y, Tanaka
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 14 Pages: 18899-18924

    • Related Report
      2013 Research-status Report
  • [Journal Article] 青梅加熱濃縮エキス成分「MK615」の医薬素材としての可能性2013

    • Author(s)
      平石勝也、神間史恵、相馬洋之、森元陽子、足立太郎、足立正一
    • Journal Title

      Personalized Medicine Universe

      Volume: 1 Pages: 17-28

    • NAID

      40021011176

    • Related Report
      2013 Research-status Report
  • [Presentation] ブラッククミン種子精油のFusobacterium nucleatumに対する抗菌作用.2015

    • Author(s)
      徳田雅行,森元陽子, 川上克子,中杉徹,村川拓士,渋谷耕司,西谷佳浩
    • Organizer
      日本歯科保存学会平成27年度秋季大会
    • Place of Presentation
      文京シビックホール(東京都文京区)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] TRPV1とAQP2を介して高浸透圧刺激による細胞傷害を回避する.2015

    • Author(s)
      徳田雅行,藤澤真理,宮下桂子,川上克子,森元陽子,鳥居光男.
    • Organizer
      日本歯科保存学会平成27年度春季大会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Presentation] ヤマブシタケ抽出物の抗菌活性―試験管内およびヒト口腔内における検討.2014

    • Author(s)
      徳田雅行,川井絢矢,作田哲也,小山徹,宮下桂子,藤澤真理,江本真規子,森元陽子,鳥居光男,松下健二
    • Organizer
      平成26年度日本歯科保存学会秋季大会(第141回)
    • Place of Presentation
      山形 (山形テルサ)
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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