| Project/Area Number |
24593163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
AWANO Shuji 九州歯科大学, 歯学部, 教授 (20301442)
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| Co-Investigator(Kenkyū-buntansha) |
SOH Inho 九州歯科大学, 歯学部, 講師 (10285463)
YOSHIDA Akihiro 松本歯科大学, 歯学部, 教授 (20364151)
ANSAI Toshihiro 九州歯科大学, 歯学部, 教授 (80244789)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ADAM17 / 歯周病 / 歯周組織 / 口腔ケラチノサイト / TNFα |
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| Outline of Final Research Achievements |
The aim of this study was to verify the possibility of a disintegrin and metalloproteinases (ADAMs), which was a family of peptidase proteins, as a target for treatment and prevention of periodontal diseases. In this study, ADAM17, which was an important enzyme of ADAMs, was focused, and it was evident that ADAM17 was prevalent in the epithelial cells of periodontal tissue. Additionally, this study showed that the levels of expression of ADAM17 and TNFα , which was a inflammatory cytokine, from the cultured oral epithelial cells and squamous cell carcinoma were enhanced by the stimulation of bacterial LPS originated form P. gingivalis, which was a pathogenic bacteria of periodontitis, and E.coli, and that there was a significant correlation between the expression of the ADAM17 and the TNFα. Thus, this study suggested that ADAM17 might be associated with the production of TNFα in gingival epithelial cells,
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