Nutritional regulation of sterol metabolism in development of lifestyle-related diseases
Project/Area Number |
24614018
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
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Research Institution | Chubu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
LU Rui 中部大学, 応用生物学部, 助教 (80381862)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | コレステロール / HDL / 動脈硬化症 / ABCA1 / cholesterol / atherosclrosis / nutritional sicences / calpain |
Outline of Final Research Achievements |
We investigated unique modulation of plasma HDL levels of Japanese focusing on the nutritional molecular regulation of the two major regulatory factors, CETP and ABCA1. 1) We found the resistance of genetic CETP deficiency, one of the major genetic causes for high HDL among Japanese, against development of hepatic cirrhosis in schistosomiasis and identified its molecular mechanism as the reason for its high prevalence in East Asia. 2) We discovered that HDL levels of Japanese markedly increased over the past 20 years reaching the higher levels than those in US by 20 %, and gave an insight to potential nutritional background for this transition. 3) We found that proteolytic regulation of ABCA1, a rate-limiting factor for HDL biogenesis, is accelerated by advanced glycation endproduct often found in DM and suppressed by inorganic nutritional factors such as Mn, Ba, Mg and Zn.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] High-density lipoprotein of Japanese has markedly increased over the past twenty years. J. Atheroscl. Thromb.2014
Author(s)
Shinji Yokoyama, Hirotsugu Ueshima, Takashi Miida, Masakazu Nakamura, Koki Takata, Tatsuyuki Fukukawa, Takaaki Goto, Mariko Harada-Shiba, Michitaka Sano, Kiminori Kato, Kazuhiro Matsuda.
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Journal Title
J. Atheroscl. Thromb.
Volume: 21
Pages: 151-160
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Validation of homogeneous assays for HDL-cholesterol using fresh samples from healthy and diseased subjects.2014
Author(s)
Miida T, Nishimura K, Okamura T, Hirayama S, Ohmura H, Yoshida H, Miyashita Y, Ai M, Tanaka A, Sumino H, Murakami M, Inoue I, Kayamori Y, Nakamura M, Nobori T, Miyazawa Y, Teramoto T, Yokoyama S
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Journal Title
Atherosclerosis
Volume: 233
Issue: 1
Pages: 252-259
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] High-density lipoprotein of Japanese has markedly increased over the past twenty years2014
Author(s)
Shinji Yokoyama, Hirotsugu Ueshima, Takashi Miida, Masakazu Nakamura, Koki Takata, Tatsuyuki Fukukawa, Takaaki Goto, Mariko Harada-Shiba, Michitaka Sano, Kiminori Kato, Kazuhiro Matsuda
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Journal Title
J. Atheroscl. Thromb
Volume: 21
Pages: 151-160
Related Report
Peer Reviewed
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[Journal Article] Background to Discuss Guidelines for Control of Plasma HDL-Cholesterol in Japan*2012
Author(s)
Yokoyama S, Yamashita S, Ishibashi S, Sone H, Oikawa S, Shirai K, Ohta T, Bujo H, Kobayashi J, Arai H, Harada-Shiba M, Eto M, Hayashi T, Gotoda T, Suzuki H, Yamada N
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 19
Issue: 3
Pages: 207-212
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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[Journal Article] Defining Patients at Extremely High Risk for Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia2012
Author(s)
Sugisawa T, Okamura T, Makino H, Watanabe M, Kishimoto I, Miyamoto Y, Iwamoto N, Yamamoto A, Yokoyama S, Harada-Shiba M
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 19
Issue: 4
Pages: 369-375
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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[Journal Article] A multicenter study on the precision and accuracy of homogeneous assays for LDL-cholesterol: Comparison with a beta-quantification method using fresh serum obtained from non-diseased and diseased subjects2012
Author(s)
Miida T, Nishimura K, Okamura T, Hirayama S, Ohmura H, Yoshida H, Miyashita Y, Ai M, Tanaka A, Sumino H, Murakami M, Inoue I, Kayamori Y, Nakamura M, Nobori T, Miyazawa Y, Teramoto T, Yokoyama S.
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Journal Title
Atherosclerosis
Volume: 225
Issue: 1
Pages: 208-15
DOI
Related Report
Peer Reviewed
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[Presentation] Probucol oxidized products, spiroquinone and diphenoquinone promote reverse cholesterol transport in mice2014
Author(s)
M. Ayaori, E. Yakushiji, S. Takiguchi, H. Uto-Kondo, M. Sasaki, M. Yogo, T. Komatsu, L. Ru, S. Yokoyama, K. Ikewaki
Organizer
European Society of Cardiology Congress
Place of Presentation
Barcelona (Spain)
Year and Date
2014-09-01
Related Report
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