Studies on an omics-analytical science investigating self-assembly supramolecules in solution

• Project/Area Number: 24619008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: オミクス計測科学
• Research Institution: Tokushima Bunri University
• Principal Investigator: YAMAGUCHI Kentro 徳島文理大学, 薬学部, 教授 (50159208)
• Co-Investigator(Kenkyū-buntansha): SETAKA Wataru 首都大学東京, 都市環境科学研究科, 准教授 (60321775) ; KAWAHATA Masatoshi 徳島文理大学, 薬学部, 講師 (00441593) ; KAZUAKI Ohara 徳島文理大学, 薬学部, 助教 (60581775)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 質量分析 / CSI-MS / 溶液化学 / 錯体形成 / 構造解析 / 有機金属錯体 / ジャイロコマ / 光学特性 / 自己組織化 / 溶液構造 / 複屈折 / 結晶構造

Outline of Final Research Achievements

The coordination compound is constructed from a metal and the organic ligand having an unshared pair of electron. Cold spray ionization mass spectrometry (CSI-MS) which we developed recently was adapted to the analysis of the resulting coordination compounds obtained from mixing a metal and two ligands. As the result, the coordination compound formation depending on the mixing ratio was detected. CSI-MS is probed to be a suitable method to analyze the construction pathways of the multiple ligand compounds.

Research Products

• [Journal Article] Coordination Oligomers and Polymers of an Oxazole-appended Zinc Chlorophyll Derivative (2014)
  • Author(s): Shinozaki, Y.; Yoshikawa, I.; Araki, K.; Ohara, K.; Yamaguchi, K.; Kawano, S.; Tanaka, K.; Araki, Y.; Wada, T.; Otsuki, J.
  • Journal Title: Chem. Lett. Volume: 43 Pages: 862-864
  • DOI: 10.1016/j.inoche.2014.03.019
  • NAID: 130004868194
  • Peer Reviewed
• [Journal Article] Coordination Oligomers and Polymers of an Oxazole-appended Zinc Chlorophyll Derivative (2014)
  • Author(s): Yoshinao Shinozaki, Isao Yoshikawa, Koji Araki, Kazuaki Ohara, Kentaro Yamaguchi, Shin-ichiro Kawano, Kentaro Tanaka, Yasuyuki Araki, Takehiko Wada, Joe Otsuki
  • Journal Title: Chemistry Letters Volume: 43 Issue: 6 Pages: 862-864
  • DOI: 10.1246/cl.140135
  • NAID: 130004868194
  • Peer Reviewed
• [Journal Article] Cold-Spray Ionization Mass Spectrometry: Applications in Structural Coordination Chemistry (2013)
  • Author(s): Yamaguchi, K.
  • Journal Title: Mass Spectrometry Volume: 2 Issue: Special_Issue Pages: S0012-S0012
  • DOI: 10.5702/massspectrometry.S0012
  • NAID: 130003380180
  • ISSN: 2186-5116, 2187-137X
  • Peer Reviewed
• [Journal Article] Solvent-dependent Assembly of Discrete and Continuous CoCl₂ Adamantane-based Ligand Complexes: Observations by CSI–Mass Spectrometry and X-ray Crystallography (2013)
  • Author(s): Ohara, K.; Tominaga, M.; Azumaya, I.; Yamaguchi, K.
  • Journal Title: Analytical Sciences Volume: 29 Issue: 8 Pages: 773-776
  • DOI: 10.2116/analsci.29.773
  • NAID: 10031190630
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed
• [Journal Article] Preparation of Tris(spiroorthocarbonate) Cyclophanes as Back to Back Ditopic Hosts (2013)
  • Author(s): Danjo, H.; Iwaso, K.; Kawahata, M.; Ohara, K.; Miyazawa, T.; Yamaguchi, K.
  • Journal Title: Org. Lett. Volume: 15(9) Pages: 2164-2167
  • Peer Reviewed
• [Journal Article] Cage Size Effects on the Rotation of Molecular Gyrotops with 1,4-Naphthalenediyl Rotor in Solution (2013)
  • Author(s): Setaka, W.; Koyama, A.; Yamaguchi, K.
  • Journal Title: Org. Lett. Volume: 15(19) Issue: 19 Pages: 5092-5095
  • DOI: 10.1021/ol402464d
  • Peer Reviewed
• [Journal Article] Order-Disorder Transition of Dipolar Rotor in a Crystalline Molecular Gyrotop and Its Optical Change (2013)
  • Author(s): Setaka, W.; Yamaguchi, K.
  • Journal Title: J. Am. Chem. Soc. Volume: 135 Issue: 39 Pages: 14560-14563
  • DOI: 10.1021/ja408405f
  • Peer Reviewed
• [Journal Article] A Molecular Balloon: Expansion of a Molecular Gyrotop Cage Due to Rotation of the Phenylene Rotor (2012)
  • Author(s): Setaka, W.; Yamaguchi, K.
  • Journal Title: J. Am. Chem. Soc. Volume: 134(30) Issue: 30 Pages: 12458-12461
  • DOI: 10.1021/ja305822e
  • Peer Reviewed
• [Journal Article] CSI-MS Measurement of Lanthanide-Series Ionic Probes for Ionic Probe Attachment Ionization (2012)
  • Author(s): F.Ito, T.Nakamura, K.Yamaguchi
  • Journal Title: Journal of the Mass Spectrometry Society of Japan Volume: 60 Issue: 2 Pages: 33-36
  • DOI: 10.5702/massspec.12-35
  • NAID: 130004479935
  • ISSN: 1340-8097, 1880-4225, 1884-3271
  • Peer Reviewed
• [Presentation] CSI-MS法による配位子比依存錯形成状態の溶液化学議論の可能性 (2014)
  • Author(s): 小原一朗，山口健太郎
  • Organizer: 日本分析化学会第63年会
  • Place of Presentation: 広島
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] Continuous Complexation of CoCl2 and Admantane-Based Ligands Observer by CSI-MS (2014)
  • Author(s): Ohara, K.; Tominaga, M.; Azumaya, I.; Yamaguchi, K.
  • Organizer: 20th International Mass Spectrometry Conference
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2014-08-24 – 2014-08-29
• [Presentation] Cold-Spray Ionization Mass Spectrometry of Coordination Complexes (2014)
  • Author(s): Ohara, K.; Yamaguchi, K.
  • Organizer: 5th Asia Oceania Mass Spectrometry Conference & 33rd Chinese Society for Mass Spectrometry Annual Conference
  • Place of Presentation: Beijing, China
  • Year and Date: 2014-07-16 – 2014-07-19
• [Presentation] 弱い相互作用からなるオリゴマー化学種の精密質量分析による追跡 (2014)
  • Author(s): 小原一朗，山口健太郎
  • Organizer: 第74回分析化学討論会
  • Place of Presentation: 福島
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] 二成分配位子によるCo錯体の精密質量による追跡 (2014)
  • Author(s): 小原一朗，綾野武司，山口健太郎
  • Organizer: 第62回質量分析総合討論会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-14 – 2014-05-16
• [Presentation] カルバゾールを有する四脚アダマンタンの球状中空構造への自己集合 (2013)
  • Author(s): 富永昌英，米田哲朗，小原一朗，山口健太郎，東屋 功
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 滋賀
• [Presentation] 環状スピロアート型分子接合素子の調製と分子認識挙動評価 (2013)
  • Author(s): 岩曽一恭，檀上博史，川幡正俊，小原一朗，山口健太郎，宮澤敏文
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 滋賀
• [Presentation] 有機多座配位子と金属からなる配位化合物のコールドスプレーイオン化質量分析法による追跡 (2013)
  • Author(s): 小原一朗，富永昌英，東屋 功，山口健太郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 滋賀
• [Presentation] 水溶性スピロボラートシクロファンの合成研究 (2013)
  • Author(s): 川幡正俊，檀上博史，山口健太郎
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 神奈川
• [Presentation] 創発解明を目指す分子ナノシステム解析法の開発 (2013)
  • Author(s): 伊藤文博，瀨髙 渉，檀上博史，山口健太郎
  • Organizer: 分子ナノシステムの創発化学領域終了シンポジウム
  • Place of Presentation: 東京
• [Presentation] Recent Applications of Cold-Spray Ionization Mass Spectrometry in Coordination Complexes (2013)
  • Author(s): Yamaguchi, K.
  • Organizer: International Conference on Frontiers of Mass Spectrometry
  • Place of Presentation: Kottayam, India
  • Invited
• [Presentation] 多成分有機架橋配位子と金属の連続的混合による配位化合物構築とコールドスプレーイオン化質量分析法 (2013)
  • Author(s): 小原一朗，伊藤文博，山口健太郎
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 水溶性スピロボラートシクロファンの合成研究 (2013)
  • Author(s): 川幡正俊，檀上博史，山口健太郎
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Book] Advances in Mass Spectrometry Volume 19 (2013)
  • Author(s): 山口健太郎 他22名
  • Total Pages: 243
  • Publisher: International Academic Publishing Co., Ltd.
• [Book] 現代質量分析学 (2013)
  • Author(s): 山口健太郎 他36名
  • Total Pages: 514
  • Publisher: 化学同人