| Project/Area Number |
24650153
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUBOTA Hiroyuki 東京大学, 理学(系)研究科(研究院), 研究員 (40376603)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インスリン / 時間パターン / システム生物学 / システムバイオロジ- / 時間情報コーディング |
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| Research Abstract |
It is reported that temporal patterns of blood insulin are important for physiological homeostasis. We revealed that the importance of temporal patterns of insulin using cultured cells, however, the importance in our body remains unknown. In this proposal, as a "Challenging Exploratory Research", we established an experimental system to stimulate rats by a direct insulin injection. As results, we can stimulate rats under conditions of (i) a somatostatine injection via jugular vein to suppress the endogenous insulin release, (ii) a glucose injection via jugular vein to maintain blood glucose level and (iii) an insulin injection via mesenteric vein.
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