Research Project
Grant-in-Aid for Challenging Exploratory Research
This study explored mechanisms which underlie how mammalian dendrites grow in vivo during neural development. Using cerebellar Purkinje cells which develop their dendrites postnatally, I investigated molecular mechanisms of dendritogenesis during 2nd postnatal week.I found that RORalpha is crucial for formation of mature dendritic branch and spines, while neuronal activities are required for stem dendrite pruning and formation of monoplanar architecture of dendritic tree.Furthermore, live imaging using two-photon microscopy revealed dynamic remodeling of developing dendrite in vivo.These results provide insights into in vivo mechanisms of dendrite formation.
All 2013 2012 Other
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)
European Journal of Neuroscience
Volume: 36 Pages: 2867-2876
Neuron
Volume: 76(2) Issue: 2 Pages: 410-422
10.1016/j.neuron.2012.10.003
