| Project/Area Number |
24650185
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tohoku University |
|---|
Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ﾌﾟﾘｵﾝ / MV2 / 感染性 / ﾉｯｸｲﾝﾏｳｽ / 新分類 / プリオン / クロイツフェルト・ヤコブ病 / 孤発性 / 感染実験 / ウエスタンブロット / ノックインマウス |
|---|
| Research Abstract |
There are MV2 cases in sporadic Creuzfeldt-Jakob disease. We established the method to classify these MV2 cases into cases with V2 prions or M2 prions. In Western blot analysis, T-1 antibody revealed Mi PrPres molecule in cases with V2 prions, while this antibody did not detected in cases with M2 prions. In cases with V2 prions, the infectivity shows the similar pattern with VV2 prions. Therefore, we established the practical classification method of MV2 prions.
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