Study on abnormal behavior induced by cytokine administration in nonhuman primates.-An attempt to produce a monkey model of schizophrenia-
| Project/Area Number |
24650215
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional basic brain science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAWA Hiroyuki 新潟大学, 脳研究所, 教授 (50183083)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | コモンマーモセット / アカゲザル / EGF / 認知機能障害 / 統合失調症 / サイトカイン / 新生児 / サル / 行動 / 胎児 |
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| Outline of Final Research Achievements |
In the present study, we investigated whether abnormal behavior could be induced by administration of cytokine in monkeys. A common marmoset monkey subcutaneously injected EGF showed hyper activity, abnormal eye movement, and a learning deficit indicating hypofrontality. Our data suggest that perinatal exposure to cytokine can be a cause of mental disorders.
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Report
(4 results)
Research Products
(2 results)
