Study on abnormal behavior induced by cytokine administration in nonhuman primates.-An attempt to produce a monkey model of schizophrenia-

Research Project

Project/Area Number	24650215
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Fusional basic brain science
Research Institution	Kyoto University
Principal Investigator	NAKAMURA Katsuki 京都大学, 霊長類研究所, 教授 (70243110)
Co-Investigator(Renkei-kenkyūsha)	NAWA Hiroyuki 新潟大学, 脳研究所, 教授 (50183083)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	コモンマーモセット / アカゲザル / EGF / 認知機能障害 / 統合失調症 / サイトカイン / 新生児 / サル / 行動 / 胎児
Outline of Final Research Achievements	In the present study, we investigated whether abnormal behavior could be induced by administration of cytokine in monkeys. A common marmoset monkey subcutaneously injected EGF showed hyper activity, abnormal eye movement, and a learning deficit indicating hypofrontality. Our data suggest that perinatal exposure to cytokine can be a cause of mental disorders.

Report

(4 results)