| Project/Area Number |
24650227
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional social brain science
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| Research Institution | Kyushu University |
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Principal Investigator |
KATO Takahiro 九州大学, 先端融合医療レドックスナビ研究拠点, 特任准教授 (70546465)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ミクログリア / ミノサイクリン / 社会的意思決定 / 信頼ゲーム / 欲動 / 性格 / うつ病 / 社会的相互性 / 精神疾患 / 社会的意志決定 / 発達 / 不安 |
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| Outline of Final Research Achievements |
Microglial social roles remain unresolved. We conducted a double-blind randomized trial of trust game, a monetary decision-making game, with human adult males who decided how much to trust an anonymous partner after a four-day administration of minocycline, an antibiotic and the most famous microglial inhibitor. The monetary score was significantly lower in the minocycline group. Participants’ ways of decision-making were significantly shifted; cooperativeness, one component of personality, proved to be the main modulating factor of decision-making in the placebo group, on the other hand, the minocycline group was mainly modulated by state anxiety and trustworthiness.
Our results suggest that minocycline led to more situation-oriented decision-making, possibly by suppressing the effects of personality traits, and that personality and social behaviors may be modulated by microglia.
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