Clarifying human social decision-making process via brain immune cells - microglia -
Project/Area Number |
24650227
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Fusional social brain science
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Research Institution | Kyushu University |
Principal Investigator |
KATO Takahiro 九州大学, 先端融合医療レドックスナビ研究拠点, 特任准教授 (70546465)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | ミクログリア / ミノサイクリン / 社会的意思決定 / 信頼ゲーム / 欲動 / 性格 / うつ病 / 社会的相互性 / 精神疾患 / 社会的意志決定 / 発達 / 不安 |
Outline of Final Research Achievements |
Microglial social roles remain unresolved. We conducted a double-blind randomized trial of trust game, a monetary decision-making game, with human adult males who decided how much to trust an anonymous partner after a four-day administration of minocycline, an antibiotic and the most famous microglial inhibitor. The monetary score was significantly lower in the minocycline group. Participants’ ways of decision-making were significantly shifted; cooperativeness, one component of personality, proved to be the main modulating factor of decision-making in the placebo group, on the other hand, the minocycline group was mainly modulated by state anxiety and trustworthiness. Our results suggest that minocycline led to more situation-oriented decision-making, possibly by suppressing the effects of personality traits, and that personality and social behaviors may be modulated by microglia.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease.2014
Author(s)
Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S
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Journal Title
Scientific Reports
Volume: 4
Issue: 1
Pages: 4957-4957
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A case of FTD with catatonia-like signs that temporarily resolved with zolpidem.2014
Author(s)
Isomura S, Monji A, Sasaki K, Baba S, Onitsuka T, Ohara T, Mizoguchi Y, Kato TA, Horikawa H, Seki Y, Kanba S
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Journal Title
Neurology: Clinical Practice
Volume: 3
Pages: 354-357
Related Report
Peer Reviewed
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[Journal Article] Minocycline, a microglial inhibitor2013
Author(s)
Watabe, M., Kato, T.A., Tsuboi, S.,Ishikawa, K., Hashiya, K., Monji, A,Utsumi, H., & Kanba, S.
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Journal Title
reduces 'honey trap' risk in human economic exchange. Scientific Report
Volume: 3
Issue: 1
Pages: 1685-1685
DOI
Related Report
Peer Reviewed
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[Journal Article] Suicide intervention skills among medical residents.2013
Author(s)
Fujisawa D, Suzuki Y, Kato TA, Hashimoto N, Sato R, Aoyama-Uehara K, Fukasawa M, Tomita M, Watanabe K, Kashima H, Otsuka K
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Journal Title
Academic Psychiatry
Volume: 37
Pages: 402-407
Related Report
Peer Reviewed
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[Journal Article] Minocycline modulates human social decision-making: Possible impact of microglia on personality-oriented social behaviors2012
Author(s)
Kato, T. A., Watabe, M., Tsuboi, S., Ishikawa, K., Hashiya, K., Monji, A Utsumi, H., & Kanba, S
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Journal Title
PLoS ONE
Volume: 7(7)
Issue: 7
Pages: 0-1
DOI
Related Report
Peer Reviewed
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[Journal Article] Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?2012
Author(s)
Watabe, M., Kato, T. A., Monji, A., Horikawa, H., & Kanba, S
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Journal Title
Psychopharmacology
Volume: 220
Issue: 3
Pages: 551-557
DOI
Related Report
Peer Reviewed
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[Presentation] A single minocycline administration suppresses methamphetamine-induced behavioral sensitization in mice.2013
Author(s)
Kato TA, Yamato M, Shiba T, Mine T, Seki Y, Ohgidani M, Sagata N, Yamauchi Y, Mizoguchi Y, Yamada K, Monji A, Kanba S
Organizer
The 43th Society for Neuroscience Annual Meeting
Place of Presentation
San Diego, USA
Related Report
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