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Clarify the acquisition and retention mechanisms of epigenetic information by use of beating cardiomyocytes

Research Project

Project/Area Number 24650253
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionHosei University (2013)
Tokyo Medical and Dental University (2012)

Principal Investigator

KANEKO Tomoyuki  法政大学, 生命科学部, 教授 (90345067)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心筋細胞 / 細胞外電位計測 / 拍動周期 / 後天的情報
Research Abstract

To quantify the epigenetic information accumulated in cells, I observed the relaxation process after adding perturbations to beating cardiomyocytes for model cells. First, I developed the system of simultaneous measurement of beating rate and field potential in beating cardiomyocytes for measurement of correlation between beating rate and active state of ion channels. Next, I measured the active state of ion channels and the beating rate on cardiomyocytes adding to perturbation for electrical stimulations, drug effects, and temperature changes. As a result, active state of ion channels was logarithmically changed by the beating rate fixed with electrical stimulation, and at the stopping of electrical stimulation it was logarithmically reverted to the active state before adding perturbation. Finally, these results were clarified a part of acquisition and retention mechanism of epigenetic information by analysis of relaxation process after perturbations.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (54 results)

All 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (44 results) Book (1 results)

  • [Journal Article] Physiological Sample Uniformity and Time-Course Stability in Lined-Up Structure of Human Cardiomyocyte Network for In vitro Predictive Drug-Induced Cardiotoxicity2013

    • Author(s)
      T. Hamada, T. Kaneko, F. Nomura, K. Yasuda
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 52 Issue: 6S Pages: 06GK05-06GK05

    • DOI

      10.7567/jjap.52.06gk05

    • NAID

      210000142395

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-Chip Single-Cell-Shape Control Technology for Understanding Contractile Motion of Cardiomyocytes Measured Using Optical Image Analysis System2013

    • Author(s)
      T. Kaneko, E. Takizawa, F. Nomura, T. Hamada, A. Hattori, K. Yasuda
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 52 Issue: 6S Pages: 06GK06-06GK06

    • DOI

      10.7567/jjap.52.06gk06

    • NAID

      210000142396

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advanced Ring-Shaped Microelectrode Assay Combined with Small Rectangular Electrode for Quasi-In vivo Measurement of Cell-to-Cell Conductance in Cardiomyocyte Network2013

    • Author(s)
      F. Nomura, T. Kaneko, T. Hamada, A. Hattori, K. Yasuda
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 52 Issue: 6S Pages: 06GK07-06GK07

    • DOI

      10.7567/jjap.52.06gk07

    • NAID

      210000142397

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exploring the implicit interlayer regulatory mechanism between cells and tissue : Stochastic mathematical analyses of the spontaneous ordering in beating synchronization2013

    • Author(s)
      H. Hamada, F. Nomura, T. Kaneko, K. Yasuda, M. Okamoto
    • Journal Title

      Biosystems

      Volume: 111 Issue: 3 Pages: 208-215

    • DOI

      10.1016/j.biosystems.2013.02.007

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] On-Chip Single-Cell-Shape Control Technology for Understanding Contractile Motion of Cardiomyocytes Measured Using Optical Image Analysis System2013

    • Author(s)
      T. Kaneko, E. Takizawa, F. Nomura, T. Hamada, A. Hattori, and K. Yasuda
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 未定

    • NAID

      210000142396

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of Electrical Stimulation Protocol for Simultaneous Measurement of Extracellular Potential with On-Chip Multi-Electrode Array System2012

    • Author(s)
      T. Kaneko, F. Nomura, A. Hattori, K. Yasuda
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 51 Issue: 6S Pages: 06FK02-06FK02

    • DOI

      10.1143/jjap.51.06fk02

    • NAID

      210000140810

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Importance of Thickness in Human Cardiomyocyte Network for Effective Electrophysiological Stimulation Using On-Chip Extracellular Microelectrodes, Jpn2012

    • Author(s)
      T. Hamada, F. Nomura, T. Kaneko, K. Yasuda
    • Journal Title

      J. Appl. Phys.

      Volume: 51 Issue: 6S Pages: 06FK03-06FK03

    • DOI

      10.1143/jjap.51.06fk03

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative Evaluation of Closed-Loop-Shaped Cardiomyocyte Network by Using Ring-Shaped Electrode2012

    • Author(s)
      F. Nomura, T. Kaneko, T. Hamada, A. Hattori, K. Yasuda
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 51 Issue: 6S Pages: 06FK06-06FK06

    • DOI

      10.1143/jjap.51.06fk06

    • NAID

      210000140814

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 幹細胞の創薬応用を目指したオンチップ・テクノロジー2012

    • Author(s)
      安田賢二、金子智行、野村典正
    • Journal Title

      ファルマシア

      Volume: 48 Pages: 823-825

    • NAID

      110009901179

    • URL

      http://farumashia.pharm.or.jp/mokuji/2012/48-09.html

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] On-chip optical image analysis system combined with on-chip single-cell-shape control technology for measurement of contractile direction and displacement on single cardiomyocytes, 18102013

    • Author(s)
      T. Kaneko, F. Nomura, T. Hamada, A. Hattori, K. Yasuda
    • Organizer
      The American Society for Cell Biology 2013 Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Measurement of contractile direction on single-shape-controlled cardiomyocytes by on-chip optical image analysis system, 2P2872013

    • Author(s)
      T. Kaneko, F. Nomura, T. Hamada, A. Hattori, K. Yasuda
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] Simultaneous dual measurement of mechanical responses and electrophysiological properties of cardiomyocytes using on-chip optical image analysis and field potential recording system, Pos-L38532013

    • Author(s)
      T. Kaneko, F. Nomura, T. Hamada, A. Hattori, K. Yasuda
    • Organizer
      57th Annual Meeting of Biophysical Society
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of On-chip quasi-in vivo cardiac toxicity assay for direct prediction of TdP occurrence using closed-loop-shaped cardiomyocyte network, 1462-Pos2013

    • Author(s)
      F. Nomura, T. Kaneko, T. Hamada, K. Yasuda
    • Organizer
      57th Annual Meeting of Biophysical Society
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Measurement of contractile direction on single-shape-controlled cardiomyocytes by on-chip optical image analysis system2013

    • Author(s)
      Tomoyuki Kaneko, Fumimasa Nomura, Tomoyo Hamada, Akihiro Hattori, Kenji Yasuda
    • Organizer
      日本生物物理学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] On-chip optical image analysis system combined with on-chip single-cell-shape control technology for measurement of contractile direction and displacement on single cardiomyocytes2013

    • Author(s)
      Tomoyuki Kaneko, Fumimasa Nomura, Tomoyo Hamada, Akihiro Hattori, Kenji Yasuda
    • Organizer
      The American Society for Cell Biology
    • Place of Presentation
      New orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Simultaneous dual measurement of mechanical responses and electrophysiological properties of cardiomyocytes using on-chip optical image analysis and field potential recording system2013

    • Author(s)
      Tomoyuki Kaneko, Fumimasa Nomura, Tomoyo Hamada, Akihiro Hattori, Kenji Yasuda
    • Organizer
      57th Annual Meeting of Biophysical Society
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] On-chip quasi-in vivo cardiac toxicity assay for direct prediction of TdP occurrence using closed-loop-shaped cardiomyocyte network2013

    • Author(s)
      Fumimasa Nomura, Tomoyuki Kaneko, Tomoyo Hamada, Kenji Yasuda
    • Organizer
      57th Annual Meeting of Biophysical Society
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Long-term simultaneous dual measurement of electrophysiological properties and mechanical responses of cardiomyocytes using on-chip extracellular field potential recording and real-time optical image analysis, No.17192012

    • Author(s)
      T. Kaneko, F. Nomura, T. Hamada, A. Hattori, K. Yasuda
    • Organizer
      The American Society for Cell Biology 2012 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Non-invasive/destructive single cell purification method for re-cultivation of functionally identified specific cells using spot digestion of double alginate sol layers on a multielectrode array chip, No.9262012

    • Author(s)
      H. Terazono, H. Kim, A. Hattori, F. Nomura, T. Kaneko, K. Yasuda
    • Organizer
      The American Society for Cell Biology 2012 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of On-Chip Dual Measurement System for Cardiac Contraction Fluctuation Assay using Simultaneous Recording of Extracellular Field Potential and Optical Image, 1P-7-932012

    • Author(s)
      T. Kaneko, F. Nomura, T. Hamada, A. Hattori, K. Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference (MNC2012)
    • Place of Presentation
      神戸メリケンパークオリエンタルホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantitative Evaluation of Quasi-electrocardiogram Measurement for Direct Prediction of Lethal Arrhythmic Beating Occurrence using Ring-shaped Cardiomyocyte Network with Ring Electrode Array, 1P-7-952012

    • Author(s)
      F. Nomura, T. Kaneko, A. Hattori, K. Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference (MNC2012)
    • Place of Presentation
      神戸メリケンパークオリエンタルホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Tempospatial External Field Potential Fluctuation Measurement in Constructive Cardiomyocyte Network for in Vitro Predictive Cardiotoxicity, 1B-4-22012

    • Author(s)
      T. Hamada, F. Nomura, T. Kaneko, K. Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference (MNC2012)
    • Place of Presentation
      神戸メリケンパークオリエンタルホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Surface Roughness of Cells as Index of Label-free Cell Identification and Separation in On-chip Imaging Cell Sorting System, 1P-7-852012

    • Author(s)
      A. Hattori, T. Kaneko, F. Nomura, K. Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference (MNC2012)
    • Place of Presentation
      神戸メリケンパークオリエンタルホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Toward quasi-in vivo from in vitro assay (I). On-chip cardiomyocyte network screening assay for predictive cardiotoxicity, No.0882012

    • Author(s)
      K. Yasuda, F. Nomura, T. Hamada, T. Kaneko, H. Takamori, Y. Abe, T. Sakakura, K. Takasuna, A. Sanbuissho
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Toward Quasi-in vivo from in vitro assay (II). Development of on-chip predictive cardiotoxicity assay for cardiac contraction fluctuation measurement using dual recording of electrical field potential and optical image analysis,No.0892012

    • Author(s)
      T. Kaneko, F. Nomura, T. Hamada, A. Hattori, K. Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Toward Quasi-In Vivo from In Vitro assay (III). Evaluation of Temporal Field Potential Duration Fluctuation and Spatial Conduction Velocity Fluctuation of Cardiomyocyte Network for In Vitro Predictive Cardiotoxicity Measurement, No.0902012

    • Author(s)
      T. Hamada, F. Nomura, T. Kaneko, H. Takamori, Y. Abe, T. Sakakura, K. Takasuna, A. Sanbuissho, K. Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Toward quasi-in vivo from in vitro assay (IV). Quasi-electrocardiogram measurement for direct prediction of TdP occurrence using ring-shaped cardiomyocyte network with ring electrode array, No.0912012

    • Author(s)
      F. Nomura, T. Kaneko, T. Hamada, K. Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Toward quasi-in vivo from in vitro assay (V). Non-invasive precise purification of ventricular cells from mixture of differentiated human stem cell derived cardiomyocytes using spot digestion of double alginate layers on a multi-electrode array chip, No.0922012

    • Author(s)
      H. Terazono, H. Kim, F. Nomura, T. Kaneko, T. Hamada, K. Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of ion channel trafficking of human stem cell derived cardiomyocytes for cardiotoxicity screening, No.0222012

    • Author(s)
      Y. Abe, T. Sakakura, K. Takasuna, A. Sanbuissho, F. Nomura, T. Hamada, T. Kaneko, K. Yasuda.
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of Dual Recording Assay for Cardiac Function Measurement using Electrical Field Potential and Optical Image Analysis, 3PS0232012

    • Author(s)
      T. Shoji, T. Kaneko, F. Nomura, A. Hattori, K. Yasuda.
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantitative evaluation of cell separation method based on shape recognition using on-chip imaging cell sorter, 3PS0492012

    • Author(s)
      A. Hattori, T. Kaneko, F. Nomura, K. Yasuda.
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] A Non-destructive Culturing and Cell Sorting Method for Cardiomyocytes and Neurons Using an Alginate Layer, 3PS0462012

    • Author(s)
      H. Terazono, H. Kim, A. Hattori, F. Nomura, T. Kaneko, K. Yasuda.
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Optimization of effective electrical stimulation protocol for cardiomyocyte beating interval control in extracellular potential measurement assay in predictive cardiotoxicity testing, 3PS0202012

    • Author(s)
      T. Kaneko, F. Nomura, K. Yasuda.
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] On-chip quasi-in vivo cardiac toxicity assay using ring-shaped closed circuit microelectrode with lined-up cardiomyocyte network, 3PS0222012

    • Author(s)
      F. Nomura, T. Kaneko, T. Hamada, K. Yasuda.
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of temporal fluctuation and spatial fluctuation on cardiomyocyte network for in vitro predictive cardiotoxicity measurement, 2D15102012

    • Author(s)
      T. Hamada, F. Nomura, T. Kaneko, K. Yasuda.
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of Dual Recording Assay for Cardiac Function Measurement using Electrical Field Potential and Optical Image Analysis2012

    • Author(s)
      Toru Shoji, Tomoyuki Kaneko, Fumimasa Nomura, Akihiro Hattori, Kenji Yasuda
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Quantitative evaluation of cell separation method based on shape recognition using on-chip imaging cell sorter2012

    • Author(s)
      Akihiro Hattori, Tomoyuki Kaneko, Fumimasa Nomura, Kenji Yasuda
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] A Non-destructive Culturing and Cell Sorting Method for Cardiomyocytes and Neurons Using an Alginate Layer2012

    • Author(s)
      Hideyuki Terazono, Hyonchol Kim, Akihiro Hattori, Fumimasa Nomura, Tomoyuki Kaneko, Kenji Yasuda
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Optimization of effective electrical stimulation protocol for cariomyocyte beating interval control in extracellular potential measurement assay in predictive cardiotoxicity testing2012

    • Author(s)
      Tomoyuki Kaneko, Fumimasa Nomura, Kenji Yasuda
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] On-chip quasi-in vivo cardiac toxicity assay using ring-shaped closed circuit microelectrode with lined-up cardiomyocyte network2012

    • Author(s)
      Fumimasa Nomura, Tomoyuki Kaneko, Tomoyo Hamada, Kenji Yasuda
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of temporal fluctuation and spatial fluctuation on cardiomyocyte network for in vitro predictive cardiotoxicity measurement2012

    • Author(s)
      Tomoyo Hamada, Fumimasa Nomura, Tomoyuki Kaneko, Kenji Yasuda
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Toward quasi-in vivo from in vitro assay (I). On-chip cardiomyocyte network screening assay for predictive cardiotoxicity2012

    • Author(s)
      Kenji Yasuda, Fumimasa Nomura, Tomoyo Hamada, Tomoyuki Kaneko, Hideo Takamori, Yasuyuki Abe, Tomoko Sakakura, Kiyoshi Takasuna, Atsushi Sanbuissho
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Toward Quasi-in vivo from in vitro assay (II). Development of on-chip predictive cardiotoxicity assay for cardiac contraction fluctuation measurement using dual recording of electrical field potential and optical image analysis2012

    • Author(s)
      Tomoyuki Kaneko, Fumimasa Nomura, Tomoyo Hamada, Akihiro Hattori, Kenji Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Toward Quasi-In Vivo from In Vitro assay (III). Evaluation of Temporal Field Potential Duration Fluctuation and Spatial Conduction Velocity Fluctuation of Cardiomyocyte Network for In Vitro Predictive Cardiotoxicity Measurement2012

    • Author(s)
      Tomoyo Hamada, Fumimasa Nomura, Tomoyuki Kaneko, Hideo Takamori, Yasuyuki Abe, Tomoko Sakakura, Kiyoshi Takasuna, Atsushi Sanbuissho, Kenji Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Toward quasi-in vivo from in vitro assay (IV). Quasi-electrocardiogram measurement for direct prediction of TdP occurrence using ring-shaped cardiomyocyte network with ring electrode array2012

    • Author(s)
      Fumimasa Nomura, Tomoyuki Kaneko, Tomoyo Hamada, Kenji Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Toward quasi-in vivo from in vitro assay (V). Non-invasive precise purification of ventricular cells from mixture of differentiated human stem cell derived cardiomyocytes using spot digestion of double alginate layers on a multi-electrode array chip2012

    • Author(s)
      Hideyuki Terazono, Hyonchol Kim, Fumimasa Nomura, Tomoyuki Kaneko, Tomoyo Hamada, Kenji Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of ion channel trafficking of human stem cell derived cardiomyocytes for cardiotoxicity screening2012

    • Author(s)
      Yasuyuki Abe, Tomoko Sakakura, Kiyoshi Takasuna, Atsushi Sanbuissho, Fumimasa Nomura, Tomoyo Hamada, Tomoyuki Kaneko, Kenji Yasuda
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Development of On-Chip Dual Measurement System for Cardiac Contraction Flu Ctuation Assay using Simultaneous Recording of Extracellular Field Potential and Optical Image2012

    • Author(s)
      Tomoyuki Kaneko, Fumimasa Nomura, Tomoyo Hamada, Akihiro Hattori, Kenji Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference(MNC2012)
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Quantitative Evaluation of Quasi-electrocardiogram Measurement for Direct Prediction of Lethal Arrhythmic Beating Occurrence using Ring-shaped Cardiomyocyte Network with Ring Electrode Array2012

    • Author(s)
      Fumimasa Nomura, Tomoyuki Kaneko, Akihiro Hattori, Kenji Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference(MNC2012)
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Tempospatial External Field Potential Fluctuation Measurement in Constructive Cardiomyocyte Network for in Vitro Predictive Cardiotoxicity2012

    • Author(s)
      Tomoyo Hamada, Fumimasa Nomura, Tomoyuki Kaneko, Kenji Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference(MNC2012)
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Surface Roughness of Cells as Index of Label-free Cell Identification and Separation in On-chip Imaging Cell Sorting System2012

    • Author(s)
      Akihiro Hattori,Tomoyuki Kaneko, Fumimasa Nomura, Kenji Yasuda
    • Organizer
      25th International Microprocesses and Nanotechnology Conference(MNC2012)
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Long-term simultaneous dual measurement of electrophysiological properties and mechanical responses of cardiomyocytes using on-chip extracellular field potential recording and real-time optical image analysis2012

    • Author(s)
      Tomoyuki Kaneko, Fumimasa Nomura, Tomoyo Hamada, Akihiro Hattori, Kenji Yasuda
    • Organizer
      The American Society for Cell Biology 2012 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Non-invasive/destructive single cell purification method for re-cultivation of functionally identified specific cells using spot digestion of double alginate sol layers on a multielectrode array chip2012

    • Author(s)
      Hideyuki Terazono, Hyonchol Kim, Akihiro Hattori, Fumimasa Nomura, Tomoyuki Kaneko, Kenji Yasuda
    • Organizer
      The American Society for Cell Biology 2012 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Book] 再生医療製品の許認可と組織工学の新しい試み2012

    • Author(s)
      安田賢二、金子智行、野村典正、服部明弘
    • Total Pages
      209
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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