| Project/Area Number |
24650254
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
TAGAWA Yoh-ichi 東京工業大学, 生命理工学研究科, 准教授 (70262079)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIYAMA Yoichi 株式会社島津製作所, デバイス部, グループ長 (80396093)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 人工臓器工学 / 再生医工学 / マイクロ流体デバイス / 肝臓 / すい臓 / 心臓 / 最小哺乳類 / in vitro生命システム / 肝組織 / 心筋 / 神経 / 胚盤胞 / 自然免疫 / 発生・分化 / 再生医学 / 細胞・組織 / バイオテクノロジー / バイオリアクター / 生物・生体工学 / 生体材料 / マイクロデバイス |
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| Research Abstract |
The vHELP, having heart, endothelium, liver, and pancreatic islet, in vitro living system was succeeded to be constructed from mouse embryonic stem cells. Some biochemical analysises could indicate that these tissue-specific functions in the vHELP. The vHELP was cultured with medium flow in the original fluidic device made from polydimethylsiloxane. Higer hepatic functions were gained by this culture in the fuluidic device.
Consequently, we have succeeded to construct mouse ES cell-derived vHELP as a minimal mammal in vitro system.
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