Analysis of immunotransporter function of the hydrophobized polysaccharide-based nanogel and its application to cancer therapy
| Project/Area Number |
24650259
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Mie University |
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Principal Investigator |
HARADA Naozumi 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (40520961)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ナノゲル / デリバリーシステム / リンパ節 / がんワクチン / マクロファージ |
|---|
| Research Abstract |
Hydrophobic polysaccharide was synthesized by partially modifying hydrophilic polysaccharide with cholesterol groups. In aqueous solution, it forms a nanogel with a diameter of ~50 nm, in which proteins or peptides can be embedded. In this study, we created a cancer vaccine consisting of the nanogel and a tumor antigen peptide, and the mechanism of antigen delivery function of the nanogel was investigated using mice. The nanogel efficiently transported antigen to unique subsets of lymph node macrophages with high antigen-presenting activity, at least partly in a cell-independent. This macrophage-oriented vaccine system showed an enhanced anti-tumor effect and immunogenicity, as compared to a conventional one.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients2013
Author(s)
Kageyama S, Wada H, Muro K, Niwa Y, Ueda S, Miyata H, Takiguchi S, Sugino SH, Miyahara Y, Ikeda H, Imai N, Sato E, Yamada T, Osako M, Ohnishi M, Harada N, Hishida T, Doki Y, Shiku H
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Journal Title
Journal of translational medicine
Volume: 5;11
Issue: 1
Pages: 246-246
DOI
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Peer Reviewed
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[Presentation] A Novel Cancer Vaccine with Nanogel-based Antigen Transporter and Sequence-optimized Long Peptide Antigen2014
Author(s)
Naozumi Harada1,2, Daisuke Muraoka1,2, Tae Hayashi1,2, Fumiyasu Momose1, Yoshiro Tahara3,4, Shin-ichi Sawada3,4, Kazunari Akiyoshi3,4, and Hiroshi Shiku1
Organizer
ITOC-1
Place of Presentation
ドイツ ミュンヘン
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[Presentation] Macrophage is a good target as antigen presenting cell to induce strong immune responses elicted with administration of vaccination antigen and immunological adjuvant2013
Author(s)
Daisuke Muraoka1,3, Naozumi Harada1,3, Tae Hayashi1,3, Momose Fumiyasu2, Shin-ichi Sawada4, Kazunari Akiyoshi4, and Hiroshi Shiku1,2
Organizer
日本免疫学会
Place of Presentation
千葉市
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