Regulating Intracellular Dynamics of Metal Nanoparticles by Bioorthogonal Chemical Reactions
| Project/Area Number |
24650261
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University |
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Principal Investigator |
ITO Takeo 京都大学, 工学(系)研究科(研究院), 助教 (80378801)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ナノ粒子 / ナノメディスン / 生体直交性反応 / 細胞内動態 / トランスロケーション / 薬剤輸送システム / 蛍光共鳴エネルギー移動 |
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| Research Abstract |
Artificially synthesized nanoparticles have been attracted much attention as novel material for drug delivery. However, little is known about the mechanisms of their accumulation in living cells and of excretion from cells. Especially, the effects of surface chemical properties of nanoparticles on the mechanisms are not clear. In this research, we have synthesized nanoparticles with cyclooctyne structure on the surface, and examined chemical conversion of the surface structures in living cells and direct observation of the reactions. We have successfully demonstrated the first example of controlling intracellular dynamics of the synthesized nanoparticles by modifying their surfaces with organ-homing molecules inside the cells.
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Report
(3 results)
Research Products
(14 results)
