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Development of antibacterial bioactive Ti metal with light environment responsiveness

Research Project

Project/Area Number 24650271
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku University

Principal Investigator

KAWASHITA Masakazu  東北大学, 医工学研究科, 准教授 (70314234)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Toshiki  九州工業大学, 大学院生命体工学研究科, 准教授 (20324973)
KANETAKA Hiroyasu  東北大学, 大学院歯学研究科, 准教授 (50292222)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords窒素ドープ酸化チタン / 可視光応答型光触媒 / 生体活性 / アパタイト / 擬似体液 / チタン / 窒素ドープ / 光触媒特性 / 可視光応答 / 光触媒 / 可視光 / 窒素 / 硫黄 / 抗菌性
Research Abstract

Ti metal treated with NaOH, NH4OH, and heat and then soaked in simulated body fluid (SBF) showed in vitro apatite formation whereas that treated with NaOH, HNO3, and heat and then soaked in SBF did not. The anatase TiO2 precipitate and/or the fine network structure formed on the surface of the Ti metal treated with NaOH, NH4OH, and heat and then soaked in SBF might be responsible for the formation of apatite on the surface of the metal. The NaOH, NH4OH, and heat treatments might produce nitrogen-doped TiO2 on the surface of the Ti metal, and the concentration of methylene blue (MB) in the Ti metal sample treated with NaOH, NH4OH, and heat decreased more than in the untreated and NaOH- and heat-treated ones. This preliminary result suggests that Ti metal treated with NaOH, NH4OH, and heat has the potential to show photocatalytic activity under visible light.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (15 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] In vitro apatite formation and visible-light photocatalytic activity of Ti metal subjected to chemical and thermal treatments2014

    • Author(s)
      M. Kawashita, Y. Yokohama, X. Y. Cui, T. Miyazaki and H. Kanetaka.
    • Journal Title

      Ceram. Int

      Volume: (印刷中) Issue: 8 Pages: 12629-12636

    • DOI

      10.1016/j.ceramint.2014.04.109

    • NAID

      120005890538

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ammonia or nitric acid treatment on surface structure, in vitro apatite formation, and visible-light photocatalytic activity of bioactive titanium metal2013

    • Author(s)
      M. Kawashita, N. Matsui, T. Miyazaki and H. Kanetaka.
    • Journal Title

      Colloids Surf. B

      Volume: Vol. 111 Pages: 503-508

    • DOI

      10.1016/j.colsurfb.2013.06.049

    • NAID

      120005890545

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Autoclave and Hot Water Treatments on Surface Structure and <i>In Vitro</i> Apatite-Forming Ability of NaOH- and Heat-Treated Bioactive Titanium Metal2013

    • Author(s)
      M. Kawashita, N. Matsui, T. Miyazaki and H. Kanetaka.
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 54 Issue: 5 Pages: 811-816

    • DOI

      10.2320/matertrans.M2013021

    • NAID

      10031168430

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design of Biomedical Materials for Treatment of Cancer and Bone Diseases2013

    • Author(s)
      川下将一
    • Journal Title

      Journal of the Japan Society of Powder and Powder Metallurgy

      Volume: 60 Issue: 12 Pages: 503-509

    • DOI

      10.2497/jjspm.60.503

    • NAID

      130003393298

    • ISSN
      0532-8799, 1880-9014
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] アンモニア雰囲気中で加熱処理した生体活性チタンのアパタイト形成能および可視光誘起光触媒特性2014

    • Author(s)
      川下将一、遠藤真子、渡辺友亮、宮崎敏樹、金高弘恭
    • Organizer
      日本セラミックス協会2014年年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] がんや骨疾患の治療に貢献する医用材料の設計2013

    • Author(s)
      川下将一
    • Organizer
      粉体粉末冶金協会平成25年度春季大会(第111回講演大会)
    • Place of Presentation
      東京
    • Year and Date
      2013-05-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of bioactive titanium metal with visible-light photocatalytic activity2013

    • Author(s)
      M. Kawashita, N. Matsui, T. Miyazaki, T. Watanabe, X.-Y. Cui and H. Kanetaka.
    • Organizer
      23rd Annual Meeting of MRS-J
    • Place of Presentation
      Yokohama, Japan.
    • Related Report
      2013 Final Research Report
  • [Presentation] Preparation of bioactive titanium metals with photocatalytic activity via anodic oxidation2013

    • Author(s)
      X. Cui, M. Kawashita, T. Xiong, Y. Yokohama, S. Furukawa and H. Kanetaka.
    • Organizer
      13th Asian BioCeramics Symposium (ABC2013)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] チタン金属表面への可視光応答型光触媒硫黄ドープ酸化チタンの形成2013

    • Author(s)
      古川崇、川下将一、崔新宇、宮崎敏樹、金高弘恭
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 可視光応答型抗菌性窒素ドープチタン金属の作製とそのアパタイト形成能評価2013

    • Author(s)
      横浜優人、川下将一、崔新宇、宮崎敏樹、金高弘恭
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 可視光誘起光触媒特性を示す生体活性チタン金属の作製2013

    • Author(s)
      川下将一、宮崎敏樹、金高弘恭
    • Organizer
      日本セラミックス協会2013年年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] アンモニア水あるいは硝酸処理が生体活性チタン金属の表面構造およびアパタイト形成能に及ぼす影響2013

    • Author(s)
      川下将一、松井真子、宮崎敏樹、金高弘恭
    • Organizer
      第51回セラミックス基礎科学討論会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] がんや骨疾患の治療に貢献する医用材料の設計2013

    • Author(s)
      川下将一
    • Organizer
      粉体粉末冶金協会平成25年度春季大会
    • Place of Presentation
      早稲田大学国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 可視光応答型抗菌性窒素ドープチタン金属の作製とそのアパタイト形成能評価2013

    • Author(s)
      横浜優人、川下将一、崔新宇、宮崎敏樹、金高弘恭
    • Organizer
      第35回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] Preparation of bioactive titanium metals with photocatalytic activity via anodic oxidation2013

    • Author(s)
      X. Cui, M. Kawashita, T. Xiong, Y. Yokohama, S. Furukawa and H. Kanetaka
    • Organizer
      13th Asian BioCeramics Symposium (ABC2013)
    • Place of Presentation
      京都大学吉田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of bioactive titanium metal with visible-light photocatalytic activity2013

    • Author(s)
      M. Kawashita, N. Matsui, T. Miyazaki, T. Watanabe, X.-Y. Cui and H. Kanetaka
    • Organizer
      23rd Annual Meeting of MRS-J
    • Place of Presentation
      横浜情報文化センター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 可視光誘起光触媒特性を示す生体活性チタン金属の作製2013

    • Author(s)
      川下将一、宮崎敏樹、金高弘恭
    • Organizer
      日本セラミックス協会2013年年会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] アンモニア水あるいは硝酸処理が生体活性チタン金属の表面構造およびアパタイト形成能に及ぼす影響2013

    • Author(s)
      川下将一、松井真子、宮崎敏樹、金高弘恭
    • Organizer
      第51回セラミックス基礎科学討論会
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of nitrogen-containing solution treatment on surface structure and apatite-forming ability of bioactive Ti metal2012

    • Author(s)
      M. Kawashita, N. Matsui, T. Miyazaki, H. Kanetaka
    • Organizer
      12th Asian BioCeramics (ABC2012) Symposium
    • Place of Presentation
      台南市(台湾)
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 生体インプラントおよびその製造方法2013

    • Inventor(s)
      川下将一
    • Industrial Property Rights Holder
      同上
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-07
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 生体インプラントおよびその製造方法2013

    • Inventor(s)
      川下将一
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-07
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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