Research Project
Grant-in-Aid for Challenging Exploratory Research
The new concept of DNA "mono-ion complex" had been established from the DNA modification method by the interaction of the alkyl group with the DNA groove. The resulting mono-ion complex has exhibited significant higher transfection activity for tibialis muscle than clinical naked DNA and commercial in vivo transfection reagent jet PEI.The achievement of transfection to mouse tibialis muscle cells with less mitosis suggests the possibility of exogenous gene transfection preserving their nucleus membrane. Therefore, the resulting tool to control nucleus event has been established for realizing the differentiation of cell with no mitosis.
All 2014 2013 2012
All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (21 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)
ACS Medicinal Chemistry Letters
Volume: (in press) Issue: 6 Pages: 639-643
10.1021/ml400493f
Polymers for Advanced Technologies
Volume: 未定 Issue: 8 Pages: 823-826
10.1002/pat.3309
Biomacromolecules
Volume: 15 Issue: 3 Pages: 997-1001
10.1021/bm401902j
Metallomics
Volume: 6 Issue: 1 Pages: 82-87
10.1039/c3mt00226h
Chemistry Letters
Volume: 42 Pages: 358-360
10031162172
Molecular Pharmaceutics
Volume: 9 Issue: 12 Pages: 3602-3605
10.1021/mp300519x
Mol. Pharmaceutics
Volume: 9 Issue: 10 Pages: 2956-2959
10.1021/mp300147v
Bioconjugate Chemistry, Bioconjugate Chemistry
Volume: 23 Issue: 7 Pages: 1437-1442
10.1021/bc300044r
