Endothelial damage caused by blood pressure measurement? Study on decrease in endothelium function following cuff occlusion and its application to diagnosis of atherosclerosis
| Project/Area Number |
24650295
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
MATSUMOTO Takeo 名古屋工業大学, 工学(系)研究科(研究院), 教授 (30209639)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYAMA Kazuaki 名古屋工業大学, 大学院工学研究科, 准教授 (10359763)
SUGITA Shukei 名古屋工業大学, 大学院工学研究科, 助教 (20532104)
YAGUCHI Toshiyuki 名古屋工業大学, 大学院工学研究科, 研究員 (70385483)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バイオメカニクス / 動脈硬化 / 血管内皮細胞 / 血管平滑筋細胞 / FMD |
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| Research Abstract |
In ordinal blood pressure measurement, a cuff attached to the upper arm is first pressurized to stop blood flow in the brachial artery and then depressurized to observe the process of blood flow restoration. During this process, the brachial artery is occluded. To know the effects of the occlusion on the brachial artery, endothelial and smooth muscle functions were measured with the FMD method that is frequently used in clinical practice and a PMC method developed in our laboratory, respectively, before and after the occlusion.
The results indicate that endothelial function but not smooth muscle function decreased following blood vessel occlusion, and recovery from this damage is faster in younger subjects. We also developed an animal model to reproduce this phenomenon.
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Report
(3 results)
Research Products
(41 results)
