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Endothelial damage caused by blood pressure measurement? Study on decrease in endothelium function following cuff occlusion and its application to diagnosis of atherosclerosis

Research Project

Project/Area Number 24650295
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionNagoya Institute of Technology

Principal Investigator

MATSUMOTO Takeo  名古屋工業大学, 工学(系)研究科(研究院), 教授 (30209639)

Co-Investigator(Kenkyū-buntansha) NAGAYAMA Kazuaki  名古屋工業大学, 大学院工学研究科, 准教授 (10359763)
SUGITA Shukei  名古屋工業大学, 大学院工学研究科, 助教 (20532104)
YAGUCHI Toshiyuki  名古屋工業大学, 大学院工学研究科, 研究員 (70385483)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsバイオメカニクス / 動脈硬化 / 血管内皮細胞 / 血管平滑筋細胞 / FMD
Research Abstract

In ordinal blood pressure measurement, a cuff attached to the upper arm is first pressurized to stop blood flow in the brachial artery and then depressurized to observe the process of blood flow restoration. During this process, the brachial artery is occluded. To know the effects of the occlusion on the brachial artery, endothelial and smooth muscle functions were measured with the FMD method that is frequently used in clinical practice and a PMC method developed in our laboratory, respectively, before and after the occlusion.
The results indicate that endothelial function but not smooth muscle function decreased following blood vessel occlusion, and recovery from this damage is faster in younger subjects. We also developed an animal model to reproduce this phenomenon.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (41 results)

All 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Acknowledgement Compliant: 2 results) Presentation (28 results) (of which Invited: 11 results) Remarks (1 results)

  • [Journal Article] Measurement of Circumferential Strain Distribution in Human Coronary Arteries with Atherosclerotic Plaque2013

    • Author(s)
      杉田修啓, 松本健郎, 増田弘毅, 佐藤正明
    • Journal Title

      TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A

      Volume: 79 Issue: 798 Pages: 177-187

    • DOI

      10.1299/kikaia.79.177

    • NAID

      130003374594

    • ISSN
      0387-5008, 1884-8338
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative measurement of the distribution and alignment of collagen fibers in unfixed aortic tissues2013

    • Author(s)
      Shukei Sugita, Takeo Matsumoto
    • Journal Title

      Journal of Biomechanics

      Volume: 46 Issue: 7 Pages: 1403-7

    • DOI

      10.1016/j.jbiomech.2013.02.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Measurement of Circumferential Strain Distribution in Rabbit Thoracic Aortas with Atherosclerotic Plaque2013

    • Author(s)
      杉田修啓, 松本健郎, 佐藤正明
    • Journal Title

      Journal of Life Support Engineering

      Volume: 25 Issue: 2 Pages: 56-62

    • DOI

      10.5136/lifesupport.25.56

    • NAID

      10031193008

    • ISSN
      1341-9455, 1884-5827
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and Evaluation of a Novel Apparatus for Noninvasive Measurement of Pressure-Cross-Sectional Area Relationship of the Brachial Artery Based on Oscillometric Method2013

    • Author(s)
      松本健郎,梅田宗紀,西林秀郎,石塚繁廣,高橋慎一
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 51 Issue: 4 Pages: 261-267

    • DOI

      10.11239/jsmbe.51.261

    • NAID

      130004947585

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of deformation of aortic wall at the microscopic level: Contribution of heterogeneous distribution of collagen fibers in the wall2013

    • Author(s)
      Shukei Sugita, Takeo Matsumoto
    • Journal Title

      Bio-medical Materials and Engineering

      Volume: 23 Issue: 6 Pages: 447-461

    • DOI

      10.3233/bme-130771

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ヒト橈骨動脈の力学特性の非侵襲計測法の確立と力学特性に対する平滑筋収縮状態の影響評価2013

    • Author(s)
      矢口俊之,武澤健司,長山和亮,益田博之,松本健郎
    • Journal Title

      ライフサポート

      Volume: 25-4 Issue: 4 Pages: 143-150

    • DOI

      10.5136/lifesupport.25.143

    • NAID

      130004840058

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yielding Phenomena of Aortic Wall and Intramural Collagen Fiber Alignment: Possible Link to Rupture Mechanism of Aortic Aneurysms2013

    • Author(s)
      Sugita S, Matsumoto T
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 8 Issue: 2 Pages: 104-113

    • DOI

      10.1299/jbse.8.104

    • NAID

      130003366816

    • ISSN
      1880-9863
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel biaxial tensile test to study failure phenomena of aortic tissues at a microscopic level: Development of a biaxial tensile mechanism and successful control of failure point2013

    • Author(s)
      Sugita S
    • Journal Title

      Biomedical Engineering OnLine

      Volume: 12:3 Issue: 1 Pages: 3-3

    • DOI

      10.1186/1475-925x-12-3

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Yielding phenomena of aortic wall and intramural collagen fiber alignment: Possible link to rupture mechanism of aortic aneurysms2013

    • Author(s)
      Sugita S
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of correlation between microscopic local strain and collagen microstructure in the aorta under biaxial stretch2013

    • Author(s)
      Sugita S
    • Journal Title

      Bio-medical Materials and Engineering

      Volume: 23

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tensile properties of vascular smooth muscle cells: Bridging vascular and cellular biomechanics (Review)2012

    • Author(s)
      Matsumoto T
    • Journal Title

      J Biomechanics

      Volume: 45 Issue: 5 Pages: 745-755

    • DOI

      10.1016/j.jbiomech.2011.11.014

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real Time Observation of Collagen Fiber Behavior in the Aorta under Equibiaxial Stretch2012

    • Author(s)
      杉田修啓, 松本健郎
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 50 Issue: 6 Pages: 687-692

    • DOI

      10.11239/jsmbe.50.687

    • NAID

      130004947557

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 血管内皮細胞糖鎖層の流れに伴う変形計測の試み2014

    • Author(s)
      高橋結宗,長山和亮,松本健郎
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 血圧測定時の血管圧平がヒト上腕動脈の内皮機能に及ぼす影響2014

    • Author(s)
      下兼司,矢口俊之,長山和亮,塚原弘政,益田博之,松本健郎
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 経壁圧操作により求めたヒト上腕動脈圧-径関係の再現性に関する検討2013

    • Author(s)
      矢口俊之,長山和亮,塚原弘政,益田博之,松本健郎
    • Organizer
      平成25年度日本生体医工学会東海支部学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel instrument for the multifaceted evaluation of artery function : Toward early-stage diagnosis of atherosclerosis2013

    • Author(s)
      Matsumoto T
    • Organizer
      International Workshop of SENSORS
    • Place of Presentation
      Nagoya(InvitedWorkshop)
    • Year and Date
      2013-07-01
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Multifaceted evaluation of artery function through its mechanical response : For early-stage diagnosis of atherosclerosis2013

    • Author(s)
      Matsumoto T
    • Organizer
      東北大学医工学研究科シンポジウムInternational Symposium on Biomedical Engineering Interface
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Heterogeneity in Microscopic Residual Stress in the Aortic Wall2013

    • Author(s)
      Matsumoto T
    • Organizer
      2013 SEM Annual Conference & Exposition on Experimental & Applied Mechanics
    • Place of Presentation
      Lombard, IL, USA(Invited symposium)
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Multifaceted Evaluation of Arterial Function through Transmural Pressure Manipulation2013

    • Author(s)
      Matsumoto T, Yaguchi T, Shimo K, Kurokawa T, Nagayama K, Tsukahara H, Masuda H
    • Organizer
      24^<th> Congress of the International Society of Biomechanics
    • Place of Presentation
      Natal, Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of microscopic heterogeneity on the mechanical behavior of the elastic arteries2013

    • Author(s)
      Matsumoto T
    • Organizer
      The 7th Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Seoul, Korea(Invited lecture)
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 経壁圧制御によるヒト上腕動脈の経壁圧-血管径関係の非侵襲計測2013

    • Author(s)
      矢口俊之,長山和亮,塚原弘政,益田博之,松本健郎
    • Organizer
      日本機械学会2013年度年次大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] 家兎頸動脈を用いたFMD再現系の確立と血管圧平が血管に与える影響の解析2013

    • Author(s)
      河口磨紀,矢口俊之,長山和亮,松本健郎
    • Organizer
      日本機械学会第24回バイオフロンティア講演会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Development of a non-invasive multifaceted evaluation system for arterial function under transmural pressure manipulation2013

    • Author(s)
      Yaguchi T, Nagayama K, Tsukahara H, Masuda H, Matsumoto T
    • Organizer
      Int. Symp. on Micro-NanoMechatronics and Human Science (MHS2013)
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Final Research Report
  • [Presentation] Heterogeneity in the intramural mechanical environment of the aorta : Estimation of stress applied to elastic laminas in a physiological state2013

    • Author(s)
      Matsumoto T, Uno Y, Nagayama K
    • Organizer
      The 15th International Conference on Biomedical Engineering (ICBME 2013)
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] Three- dimensional observation of microscopic structure of the aortas reveals their heterogeneous deformation2013

    • Author(s)
      Iijima S, Nakamura S, Yokota H, Nagayama K, Matsumoto T
    • Organizer
      The 15th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel instrument for the multifaceted evaluation of artery function: Toward early-stage diagnosis of atherosclerosis2013

    • Author(s)
      Matsumoto T
    • Organizer
      International Workshop of SENSORS
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Multifaceted Evaluation of Arterial Function through Transmural Pressure Manipulation2013

    • Author(s)
      Takeo Matsumoto, Toshiyuki Yaguchi, Kenji Shimo, Takahiro Kurokawa, Kazuaki Nagayama, Hiromasa Tsukahara, Hiroshi Masuda
    • Organizer
      24th Congress of the International Society of Biomechanics
    • Place of Presentation
      Natal &#8211; Rio Grande do Norte, Brazil
    • Related Report
      2013 Annual Research Report
  • [Presentation] 経壁圧制御によるヒト上腕動脈の経壁圧-血管径関係の非侵襲計測2013

    • Author(s)
      矢口俊之,長山和亮,塚原弘政,益田博之,松本健郎
    • Organizer
      日本機械学会2013年度年次大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of a non-invasive multifaceted evaluation system for arterial function under transmural pressure manipulation2013

    • Author(s)
      Yaguchi T, Nagayama K, Tsukahara H, Masuda H, Matsumoto T
    • Organizer
      Int. Symp. on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Annual Research Report
  • [Presentation] Multifaceted evaluation of artery function through its mechanical response: For early-stage diagnosis of atherosclerosis2013

    • Author(s)
      Matsumoto T
    • Organizer
      International Symposium on Biomedical Engineering Interface
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Multifaceted Evaluation of Arterial Function through Transmural Pressure Manipulation2013

    • Author(s)
      Matsumoto T
    • Organizer
      24th Congress of the International Society of Biomechanics
    • Place of Presentation
      Natal, Brazil
    • Related Report
      2012 Research-status Report
  • [Presentation] Tensile Properties of Vascular Smooth Muscle Cells : Bridging Tissue and Cell Biomechanics2012

    • Author(s)
      Matsumoto T
    • Organizer
      バイオフロンティアシンポジウム2012
    • Place of Presentation
      弘前(Keynote Lecture)
    • Year and Date
      2012-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管壁のバイオメカニクス2012

    • Author(s)
      松本健郎
    • Organizer
      第2回豊橋ライブデモンストレーションコース
    • Place of Presentation
      豊橋
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 3次元内部構造顕微鏡を用いた家兎胸大動脈壁内微細構造の観察2012

    • Author(s)
      飯島慎太郎,長山和亮,中村佐紀子,横田秀夫,松本健郎
    • Organizer
      日本機械学会第23回バイオフロンティア講演会
    • Place of Presentation
      弘前
    • Related Report
      2013 Final Research Report
  • [Presentation] Heterogeneity in Microscopic Deformation of Aortic Wall during Circumferential Stretch2012

    • Author(s)
      Matsumoto T, Uno Y, Nagayama K
    • Organizer
      BMES 2012 Annual Meeting
    • Place of Presentation
      Atlanta, GA, USA
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] ヒト腕動脈内圧−径関係の非侵襲的計測の試み2012

    • Author(s)
      矢口俊之,武澤健司,長山和亮,益田博之,松本健郎
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2012
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管壁のバイオメカニクス2012

    • Author(s)
      松本 健郎
    • Organizer
      第2回豊橋ライブデモンストレーションコース
    • Place of Presentation
      豊橋
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 生体組織内の応力分布の推定-血管壁・Xenopus 胚を例に-2012

    • Author(s)
      松本 健郎
    • Organizer
      第1回多細胞動態研究のためのブレインストーミング・ワークショップ
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Tensile Properties of Vascular Smooth Muscle Cells: Bridging Tissue and Cell Biomechanics2012

    • Author(s)
      Matsumoto T
    • Organizer
      バイオフロンティアシンポジウム2012
    • Place of Presentation
      弘前
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Uniform stress hypothesisは正しいか?微視的視点から見た大動脈壁内力学環境の不均質性2012

    • Author(s)
      松本 健郎
    • Organizer
      日本バイオレオロジー学会創立35周年記念シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Remarks] 名古屋工業大学バイオメカニクス研究室

    • URL

      http://biomech.web.nitech.ac.jp/top.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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