Development of new bubble with fluorous chemistry
Project/Area Number |
24650299
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Medical systems
|
Research Institution | Teikyo University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | マイクロバブル / 超音波 / セラノスティクス / フルオラスケミストリー / セラノスティックス |
Research Abstract |
C3F8 encapsulated bubble liposome was developed under fluoras-chemistry. Liposome was prepared with F-palmitoyl phosphatidylcholine (F-DPPC, 2F-DPPC), DSPC and DSPE-PEG2000-OMe, and C3F8 was encapsulated to make bubble liposome. The presence of F-DPPC increased C3F8 encapsulation rate. To aim at the practical use of bubble liposome, freeze dry formulation of bubble liposome was examined. Rehydration of freeze dried bubble liposome showed same property of bubble liposome in size, ultrasound imaging and cavitation.
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Report
(3 results)
Research Products
(11 results)