Development of new bubble with fluorous chemistry

• Project/Area Number: 24650299
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Teikyo University
• Principal Investigator: MARUYAMA Kazuo 帝京大学, 薬学部, 教授 (30130040)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: マイクロバブル / 超音波 / セラノスティクス / フルオラスケミストリー / セラノスティックス

Research Abstract

C3F8 encapsulated bubble liposome was developed under fluoras-chemistry. Liposome was prepared with F-palmitoyl phosphatidylcholine (F-DPPC, 2F-DPPC), DSPC and DSPE-PEG2000-OMe, and C3F8 was encapsulated to make bubble liposome. The presence of F-DPPC increased C3F8 encapsulation rate. To aim at the practical use of bubble liposome, freeze dry formulation of bubble liposome was examined. Rehydration of freeze dried bubble liposome showed same property of bubble liposome in size, ultrasound imaging and cavitation.

Research Products

• [Journal Article] Anti-tumor effect of NF-ĸB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites (2014)
  • Author(s): Kono Yusuke, Kawakami Shigeru, Higuchi Yuriko, Maruyama Kazuo, Yamashita Fumiyoshi, Hashida Mitsuru
  • Journal Title: Cancer Science Volume: (in press)
  • Peer Reviewed
• [Journal Article] Evaluation of active control of Bubble liposomes in a bifurcated flow under various ultrasound conditions (2014)
  • Author(s): Ren Koda, Jun Koido, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda, Ryo Suzuki, Kazuo Maruyama
  • Journal Title: Advanced Biomedical Engineering Volume: 3 Pages: 21-28
  • NAID: 130004568027
  • Peer Reviewed
• [Journal Article] Anti-tumor effect of NF-ĸB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites (2014)
  • Author(s): Kono Yusuke, Kawakami Shigeru, Higuchi Yuriko, Maruyama Kazuo, Yamashita Fumiyoshi, Hashida Mitsuru
  • Journal Title: Cancer Science
  • Peer Reviewed
• [Presentation] 超音波セラノスティックス(THERANOSTICS) (2013)
  • Author(s): 丸山一雄
  • Organizer: 第13回遺伝子・デリバリー研究会シンポジウム
  • Place of Presentation: 帝京大学
  • Year and Date: 2013-05-11
  • Invited
• [Presentation] 超音波セラノスティクスシステムの開発 (2013)
  • Author(s): 丸山一雄
  • Organizer: 第16回ヒューマンサイエンス総合研究
  • Place of Presentation: 東京(ワークショップ)
• [Presentation] 超音波セラノスティクスシステムの開発 (2013)
  • Author(s): 丸山一雄
  • Organizer: 第１６回ヒューマンサイエス総合研究ワークショップ
  • Place of Presentation: 東京
• [Presentation] Gene Delivery System by Cavitation of Bubble Liposome and Ultrasound in Cancer Therapy (2012)
  • Author(s): Kazuo Maruyama, Yusuke Oda, Ryo Suzuki
  • Organizer: 8th International Symposium on Cavitation
  • Place of Presentation: シンガポール
• [Presentation] Gene Delivery System by Cavitation of Bubble Liposome and Ultrasound in Cancer Therapy (2012)
  • Author(s): Kazuo Maruyama, Yusuke Oda, Ryo Suzuki
  • Organizer: 8th International Symposium on Cavitation
  • Place of Presentation: Novotel シンガポール
• [Presentation] 超音波セラノスティックス（THERANOSTICS）
  • Author(s): 丸山一雄
  • Organizer: 第13回遺伝子・デリバリー研究会シンポジウム
  • Place of Presentation: 帝京大学 板橋キャンパス
  • Invited
• [Presentation] 超音波セラノスティックス（THERANOSTICS）
  • Author(s): 丸山一雄
  • Organizer: 第13回遺伝子・デリバリー研究会シンポジウム
  • Place of Presentation: 帝京大学板橋キャンパス
  • Invited
• [Remarks]
  • URL: http://www.teikyo-dds-lab.com