Research Project
Grant-in-Aid for Challenging Exploratory Research
I succeeded to generate and sort novel mesenchymal stem cells (MSCs)from mouse ES cells. The MSCs showed high differentiation potential to skeletal muscle cells, therefore I aimed to develop useful transplantation technique for the regeneration of muscle tissues with functional recovery by MSCs. I also wished to study regeneration mechanism of the skeletal muscle tissue. The results of the investigation are as follows: (1) Tibialis anterior muscles were crushed and used as injured muscle models. Direct transplantation of MSCs into the injured muscle after 24 hours of crush showed effective regeneration. (2)MSCs differentiated into either skeletal muscle cells or blood vessels and induced peripheral nerve fiber's extension to accelerate the recovery. (3) Transplantation of MSCs accelerated the functional recovery of the muscle more than 1 week.
All 2014 2013 2012 2011 Other
All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (25 results) (of which Invited: 2 results) Remarks (3 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 3 results)
BioResearch Open Access
Volume: 2巻, 4号 Issue: 4 Pages: 295-306
10.1089/biores.2013.0012
Stem Cell Discovery
Volume: 2 Issue: 02 Pages: 70-77
10.4236/scd.2012.22011
日本基礎理学療法学雑誌
Volume: 16 Pages: 9-15
130007491875
Differentiation
Volume: 82(3) Issue: 3 Pages: 153-164
10.1016/j.diff.2011.07.001
http://plaza.umin.ac.jp/~st-home/index.html
