| Project/Area Number |
24650406
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAURA Yasuyuki 名古屋大学, 大学院生命農学研究科, 助教 (90442954)
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| Co-Investigator(Renkei-kenkyūsha) |
KADOTA Yoshihiro 名古屋大学, 大学院生命農学研究科, 特別研究員 (10724776)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分岐鎖アミノ酸 / 分岐鎖α-ケト酸脱水素酵素キナーゼ / コンディショナルノックアウト / マウス / 筋 / 神経 / 分岐鎖アミノ酸分解系 / コンディショナルノックアウトマウス / 脳・神経 |
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| Research Abstract |
Branched-chain amino acid metabolism is suppressed by branched-chain alpha-ketoacid dehydrogenase kinase (BDK). In the present study, we have prepared conditional BDK-knockout (KO) mice to clarify the physiological functions of BCAAs. We first produced BDK-floxed mice for preparation of conditional BDK-KO mice. Using the mice, we prepared global (whole body) BDK-KO mice, and then muscle-specific BDK-KO mice, and now preparation of nerve-specific BDK-KO mice is ongoing. The conditional BDK-KO mice have a tissue-specific deficiency of BCAAs. Specific features of these mice are becoming to be clarified.
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