| Project/Area Number |
24650504
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kagawa Nutrition University |
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Principal Investigator |
HIRAISHI Sayuri 女子栄養大学, 栄養科学研究所, 講師 (20150659)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 栄養学 / 概日リズム / 癌転移 / 食生活 |
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| Research Abstract |
The expression of clock genes that modulate circadian rhythms rises and falls over a 24-h period. Feeding mice during the daytime when they normally rest led to a shift in the peak expression time of clock genes and significantly promoted cancer metastasis. Moreover, compared with wild-type mice, the number of metastatic nodules was significantly increased in the lungs of Clock mutant mice with abnormalities in CLOCK protein function, indicating that disruptions in circadian rhythm promoted cancer metastasis. Prolonging abnormal feeding times also appeared to increase the mRNA expression of both P-selectin and Vcam-1 adhesion molecules in the lungs.
These findings suggest that the inability to maintain a regular meal time may disrupt the circadian rhythms of circadian clock genes and affect expression of some adhesion molecules, thereby promoting cancer metastasis.
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