| Project/Area Number |
24650621
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Kobe University |
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Principal Investigator |
TOKUDA Emi 神戸大学, 医学(系)研究科(研究院), 医学研究員 (30598925)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 上皮間葉転換 / ゴルジ体 / イノシトールリン脂質 / がん |
|---|
| Research Abstract |
In this study, I showed that phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus regulates epithelial-mesenchymal transition during cancer progression.
Increasing PI4P level in the Golgi apparatus resulted in decreased cell-cell adhesion and increased cell migration which is characteristic of epithelial-mesenchymal transition. In contrast, decreasing PI4P in the Golgi apparatus resulted in increased cell-cell adhesion and decreased invasion. Furthermore, PI4P level in the Golgi apparatus was increased in malignant breast cancer cell lines and malignant breast cancer patient. I also showed that GOLPH3, which is known to localize in the Golgi apparatus and bind to PI4P, was involved in the generation of these phenotypes in a manner that depends on its PI(4)P-binding ability.
These results suggest that PI4P in the Golgi apparatus plays an important role in cancer progression.
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