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Phosphoinositide in the Golgi apparatus regulates epithelial-mesenchymal transition

Research Project

Project/Area Number 24650621
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Tumor biology
Research InstitutionKobe University

Principal Investigator

TOKUDA Emi  神戸大学, 医学(系)研究科(研究院), 医学研究員 (30598925)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords上皮間葉転換 / ゴルジ体 / イノシトールリン脂質 / がん
Research Abstract

In this study, I showed that phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus regulates epithelial-mesenchymal transition during cancer progression.
Increasing PI4P level in the Golgi apparatus resulted in decreased cell-cell adhesion and increased cell migration which is characteristic of epithelial-mesenchymal transition. In contrast, decreasing PI4P in the Golgi apparatus resulted in increased cell-cell adhesion and decreased invasion. Furthermore, PI4P level in the Golgi apparatus was increased in malignant breast cancer cell lines and malignant breast cancer patient. I also showed that GOLPH3, which is known to localize in the Golgi apparatus and bind to PI4P, was involved in the generation of these phenotypes in a manner that depends on its PI(4)P-binding ability.
These results suggest that PI4P in the Golgi apparatus plays an important role in cancer progression.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.2014

    • Author(s)
      Tokuda, E., Itoh, T., Hasegawa, J., Ijuin, T., Takeuchi, Y., Irino, Y., Fukumoto, M., Takenawa, T.
    • Journal Title

      Cancer Res.

      Volume: 74 Issue: 11 Pages: 3054-3066

    • DOI

      10.1158/0008-5472.can-13-2441

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 乳がん細胞株においてゴルジ体のイノシトールリン脂質が細胞間接着と細胞運動・浸潤能を制御する2013

    • Author(s)
      徳田恵美、伊藤俊樹、竹縄忠臣
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Related Report
      2013 Final Research Report
  • [Presentation] 乳がん細胞株においてゴルジ体のイノシトールリン脂質が細胞間接着と細胞運動・浸潤能を制御する2013

    • Author(s)
      徳田恵美、伊藤俊樹、竹縄忠臣
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      ウインクあいち(愛知県)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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