Phosphoinositide in the Golgi apparatus regulates epithelial-mesenchymal transition
| Project/Area Number |
24650621
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
TOKUDA Emi 神戸大学, 医学(系)研究科(研究院), 医学研究員 (30598925)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 上皮間葉転換 / ゴルジ体 / イノシトールリン脂質 / がん |
|---|
| Research Abstract |
In this study, I showed that phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus regulates epithelial-mesenchymal transition during cancer progression.
Increasing PI4P level in the Golgi apparatus resulted in decreased cell-cell adhesion and increased cell migration which is characteristic of epithelial-mesenchymal transition. In contrast, decreasing PI4P in the Golgi apparatus resulted in increased cell-cell adhesion and decreased invasion. Furthermore, PI4P level in the Golgi apparatus was increased in malignant breast cancer cell lines and malignant breast cancer patient. I also showed that GOLPH3, which is known to localize in the Golgi apparatus and bind to PI4P, was involved in the generation of these phenotypes in a manner that depends on its PI(4)P-binding ability.
These results suggest that PI4P in the Golgi apparatus plays an important role in cancer progression.
|
Report
(3 results)
Research Products
(3 results)
-
[Journal Article] Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.2014
Author(s)
Tokuda, E., Itoh, T., Hasegawa, J., Ijuin, T., Takeuchi, Y., Irino, Y., Fukumoto, M., Takenawa, T.
-
Journal Title
Cancer Res.
Volume: 74
Issue: 11
Pages: 3054-3066
DOI
Related Report
Peer Reviewed / Open Access
-
-
