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A novel cancer vaccine produced with cell reprogramming

Research Project

Project/Area Number 24650628
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Tumor immunology
Research InstitutionHokkaido University

Principal Investigator

SEINO kenichiro  北海道大学, 遺伝子病制御研究所, 教授 (20312845)

Co-Investigator(Kenkyū-buntansha) WADA Haruka  北海道大学, 遺伝子病制御研究所, 講師 (70392181)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん幹細胞
Research Abstract

Recently, it has been suggested that there is a stem cell fraction in cancer. To establish an efficient therapy against cancer, it is reasonable to target the cancer stem cells. In this study, we have examined immunological features of cancer stem cells. We have obtained mouse glioma stem and non-stem cells. When examined there cell surface phenotype, we found that MHC class I was expressed higher in the stem cells than in non-stem cells. MHC class I is known as a suppressor molecule for NK cells. Then, we performed NK cell mediated cytotoxicity assay. In this sassy, the cancer stem fraction were killed more than no stem fraction. Therefore, it was suggested that cancer stem cells suppress NK cell function and then obtained the tumor-initiating capacity.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (12 results) (of which Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Mouse models of human INAD by Pla2g6 deficiency2013

    • Author(s)
      Wada H, Kojo S, and Seino K
    • Journal Title

      Histol Histopathol

      Volume: 28 Pages: 965-969

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞治療による免疫寛容の誘導2013

    • Author(s)
      工藤浩也、和田はるか、清野研一郎
    • Journal Title

      今日の移植

      Volume: 25巻4号 Pages: 293-300

    • Related Report
      2013 Final Research Report
  • [Journal Article] 移植免疫制御を担うNKT細胞2012

    • Author(s)
      清野研一郎
    • Journal Title

      血液フロンティア

      Volume: 23巻7号 Pages: 41-45

    • Related Report
      2013 Final Research Report
  • [Journal Article] 移植と免疫2012

    • Author(s)
      工藤浩也、和田はるか、清野研一郎
    • Journal Title

      medicina

      Volume: 50巻3号 Pages: 416-418

    • Related Report
      2013 Final Research Report
  • [Presentation] A novel methodology of immune regulation using pluripotent stem cells2013

    • Author(s)
      Hiroya Kudo, Haruka Wada, Satoshi Kojo, Tatsuya Chikaraishi, Ken-ichiro Seino
    • Organizer
      CiRA International Symposium 2013
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-03-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Transcriptional regulator bHLHe40 works as a cofactor of T-bet in the regulation of iNKT cell IFN-g production2013

    • Author(s)
      Kojo S, Yamanaka H, Wada H, Harada M, Nyambayar D, Taniguchi M, Seino K
    • Organizer
      第42日本免疫学会
    • Place of Presentation
      幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] Induction of M2-like immunoregulatory cells from ES cells2013

    • Author(s)
      Haruka Wada, Ken-ichiro Seino
    • Organizer
      4th Synthetic Immunology Workshop
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Induction of M2-like immunoregulatory cells from ES cells2013

    • Author(s)
      Hiroya Kudo, Haruka Wada, Satoshi Kojo, Tatsuya Chikaraishi, Ken-ichiro Seino
    • Organizer
      15th International Congress for Immunology
    • Place of Presentation
      Milan
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel methodology of immune regulation using pluripotent stem cells2013

    • Author(s)
      Hiroya Kudo, Haruka Wada, Satoshi Kojo, Tatsuya Chikaraishi, Ken-ichiro Seino
    • Organizer
      ISSCR 11th Annual Meeting
    • Place of Presentation
      Boston
    • Related Report
      2013 Final Research Report
  • [Presentation] 多能性幹細胞を用いた再生医療時代の免疫制御2013

    • Author(s)
      清野研一郎
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 多能性幹細胞を用いた免疫制御法に関する研究2013

    • Author(s)
      工藤浩也、和田はるか、香城諭、力石辰也、清野研一郎
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 多能性幹細胞を用いた免疫制御法に関する研究2012

    • Author(s)
      工藤浩也、和田はるか、香城諭、力石辰也、清野研一郎
    • Organizer
      第16回北海道移植フォーラム
    • Place of Presentation
      旭川
    • Year and Date
      2012-07-14
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel methodology of immune regulation using pluripotent stem cells2012

    • Author(s)
      Ken-ichiro Seino
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-05
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 再生医学時代における新しい免疫制御法の考え方2012

    • Author(s)
      清野研一郎
    • Organizer
      第21回泌尿器科分子・細胞研究会
    • Place of Presentation
      札幌
    • Year and Date
      2012-02-10
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 多能性幹細胞を用いた免疫制御法に関する研究2012

    • Author(s)
      工藤浩也、和田はるか、香城諭、力石辰也、清野研一郎
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 多能性幹細胞を用いた免疫制御法に関する研究2012

    • Author(s)
      工藤浩也、和田はるか、香城諭、力石辰也、清野研一郎
    • Organizer
      第48回日本移植学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Book] 移植片に対する反応.in標準免疫学第3版(監修:谷口克)2013

    • Author(s)
      清野研一郎
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.igm.hokudai.ac.jp/Immunobiology-Web/Home.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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