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cryoimmunotherapy for malignant bone tumors

Research Project

Project/Area Number 24650631
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Tumor immunology
Research InstitutionKanazawa University

Principal Investigator

TSUCHIYA Hiroyuki  金沢大学, 医学系, 教授 (40227434)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords凍結免疫 / 凍結免疫療法 / 骨軟部腫瘍 / 免疫
Research Abstract

The purpose of this study is that the cryotreatment of tumor tissue may induced anti tumor effect, and that suppressed tumor recurrence and metastases. We have treated 25 patients for malignant tumors who failed standard treatment of surgery, chemotherapy, and radiotherapy. Then we started dendritic cell immunotherapy generated extra vivo, which pulsed with cryotreated tumor tissue mixed with OK-432. 3o% of patients induced immunological reactions. After that, we planed that the patients treated by cry treatment using liquid nitrogen combined with dendritic cell immunotherapy to reduce local recurrence and metastasis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results) (of which Invited: 5 results)

  • [Journal Article] Innovative antimicrobial coating of titanium implants with iodine2012

    • Author(s)
      Tsuchiya H, Shirai T, Nishida H, Murakami H, Kabata T, Yamamoto N, Watanabe K, Nakase J
    • Journal Title

      J Orthop Sci

      Volume: 5 Issue: 5 Pages: 595-604

    • DOI

      10.1007/s00776-012-0247-3

    • NAID

      120004966630

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Immunotherapy based on dendritic cells is feasible for patients with malignant bone and soft tissue tumours2013

    • Author(s)
      Hideji Nishida, Norio Yamamoto, Akihiko Takeuchi, Yoshikazu Tanzawa, Hiroaki Kimura, Munetomo Takata, Isei Nomura, Shinji Miwa, Takashi Kato, Hiroyuki Tsuchiya
    • Organizer
      26th European Musculoskeletal Oncology Society Meeting
    • Place of Presentation
      ヨーテボリ、スウェーデン
    • Related Report
      2013 Final Research Report
  • [Presentation] Controversy of orthopedic oncology: Biological reconstruction2013

    • Author(s)
      Tsuchiya H
    • Organizer
      The 45th Brazilian Congress of Orthopaedics and Traumatology 2013
    • Place of Presentation
      Curitiba, Parana, Brazil
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Immunotherapy based on dendritic cells is feasible for patients with malignant bone and soft tissue tumours2012

    • Author(s)
      Hideji Nishida, Yoshikazu Tanzawa, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroaki Kimura, Shingo Shimozaki, Hiroyuki Tsuchiya
    • Organizer
      9^<th> Asian Pacific Musculoskeletal Tumor Society
    • Place of Presentation
      クアラルンプール、マレーシア
    • Related Report
      2013 Final Research Report
  • [Presentation] ここまで来た骨腫瘍再建術2012

    • Author(s)
      土屋弘行
    • Organizer
      第85回 日本整形外科学会学術総会
    • Place of Presentation
      国立京都国際会館、京都市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Biological limb reconstruction for tumor surgery2012

    • Author(s)
      Tsuchiya H
    • Organizer
      7th ASAMI International Meeting & Bone Reconstruction 2012
    • Place of Presentation
      Hyatt Regency Hotel,Thessaloniki city, Greece
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Antimicrobial iodine-coated titanium implants for orthopedic surgery2012

    • Author(s)
      Tsuchiya H
    • Organizer
      7th ASAMI International Meeting & Bone Reconstruction 2012
    • Place of Presentation
      Hyatt Regency Hotel, Thessaloniki city, Greece
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 腫瘍外科医の限りなき挑戦2012

    • Author(s)
      土屋弘行
    • Organizer
      第45回 日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      東京国際フォーラム、東京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 10. Progress of osteosarcoma treatment: Ultimate conservative surgery in conjunction with caffeine-potentiated chemotherapy2012

    • Author(s)
      Tsuchiya H
    • Organizer
      17th World Congress on Advances in Oncology and 15th International Symposium on Molecular Medicine
    • Place of Presentation
      Creta Maris Hotel, Crete city, Greece
    • Related Report
      2012 Research-status Report
  • [Presentation] 腫瘍再建術の最前線2012

    • Author(s)
      土屋弘行
    • Organizer
      兵庫医大整形外科開講記念学術講演会
    • Place of Presentation
      ノボテル甲子園、西宮市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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