The establishment of synthetic design guide for emission maximum of luciferin analogue
| Project/Area Number |
24650633
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
MAKI Shojiro 電気通信大学, 情報理工学(系)研究科, 助教 (20266349)
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| Co-Investigator(Kenkyū-buntansha) |
NIWA Haruki 電気通信大学, 大学院情報理工学研究科, 教授 (20135297)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 近赤外発光 / ルシフェリン / ルシフェラーゼ / ホタル生物発光 / インビボイメージング / 有機合成 / 人為制御 / 指標 / 生物発光 / 蛍光 / ホタル / 波長制御 / バイオイメージング / 発癌 / 癌転移 / 再生医療 / 脳神経 / 標識材料 / 癌 / 長波長発光 |
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| Outline of Final Research Achievements |
We have reached a goal innovating new luciferin analogue having 700nm emission maximum. Besides, we have found emission maximum control method for “NIR luciferin Aka Lumine” by replacing just one atom from C to N, on aromatic site of “NIR luciferin Aka Lumine”.
When the C5 position on the aromatic site of “Aka Lumine” replaced, the emission maximum has been blue shift ca. 50nm. However, when the C2 position on the aromatic site of “Aka Lumine” replaced, the emission maximum has been not shifted.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light2013
Author(s)
Satoshi Iwano, Rika Obata, Chihiro Miura, Masahiro Kiyama, Kazutoshi Hama, Mitsuhiro Nakamura, Yoshiharu Amano, Satoshi Kojima, Takashi Hirano, Shojiro Maki, Haruki Niwa
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Journal Title
Tetrahedron
Volume: 69
Pages: 3847-3856
Related Report
Peer Reviewed
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[Presentation] 新規近赤外ルシフェリンアナログの創製2015
Author(s)
大塚 智史, 木山 正啓, 北田 昇雄, 齊藤 亮平, 平野 誉, 牧 昌次郎
Organizer
日本癌学会シンポジウム（金沢）
Place of Presentation
石川県立音楽堂交流ホール
Year and Date
2015-01-21 – 2015-01-22
Related Report
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[Presentation] 新規近赤外ルシフェリンアナログの創製2014
Author(s)
大塚 智史, 木山 正啓, 北田 昇雄, 齊藤 亮平, 平野 誉, 牧 昌次郎
Organizer
第３７回日本分子生物学会年会（横浜）
Place of Presentation
パシフィコ横浜
Year and Date
2014-11-25 – 2014-11-27
Related Report
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