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The initial diagnosis for lung cancer using isotope ratio

Research Project

Project/Area Number 24650635
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Tumor diagnosis
Research InstitutionAkita Prefectural University

Principal Investigator

KAWASHIMA Hiroto  秋田県立大学, システム科学技術学部, 助教 (60381331)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords肺がん / 初期診断 / 安定同位体比 / 分析化学 / 腫瘍診断学 / 呼気診断 / 揮発性有機化合物 / 加熱濃縮器 / 加熱濃縮
Research Abstract

For the development of the inspection method for lung cancer, we conducted various tests. As the results, the developed method can be measured lot of VOCs for high accuracy, and reduced a patient burden by small exhalation. As the exhalation test, there is almost no difference exhalation by different food and no long time by prohibited food and drinks before exhalation test. The exhalation for smokers included benzene than non-smoker. The benzene of exhalation was decreasing after smoking 6 hours. And, the exhalation for smoking menthol cigarettes included high level benzene and toluene. Using thermal desorption system, carbon isotope for many VOCs can be measured for high precision and accuracy.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Measurement of the stable carbon isotope ratio of atmospheric volatile organic compounds using chromatography, combustion, and isotope ratio mass spectrometry coupled with thermal desorption2014

    • Author(s)
      Hiroto Kawashima, Mai Murakami
    • Journal Title

      Atmospheric Environment

      Volume: vol.89 Pages: 140-147

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen isotope analysis of benzene and toluene emitted from vehicles2013

    • Author(s)
      Nami Kikuchi, Hiroto Kawashima
    • Journal Title

      Atmospheric Environment

      Volume: vol.72 Pages: 151-158

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Stable hydrogen isotope ratios and fractionation factors of VOCs during ultraviolet irradiation2013

    • Author(s)
      Nami Kikuchi, Hiroto Kawashima
    • Organizer
      Abstract of 5th FIRMS network conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Stable hydrogen isotope ratios and fractionation factors of VOCs during ultraviolet irradiation2013

    • Author(s)
      Nami Kikuchi, Hiroto Kawashima
    • Organizer
      5th FIRMS network conference
    • Place of Presentation
      Montreal
    • Related Report
      2013 Annual Research Report
  • [Presentation] 光化学反応によるベンゼン,トルエンの水素安定同位体の同位体効果2012

    • Author(s)
      菊池奈美,川島洋人
    • Organizer
      大気環境学会年会講演要旨集
    • Place of Presentation
      (vol.53)
    • Related Report
      2013 Final Research Report
  • [Presentation] 光化学反応によるベンゼン,トルエンの水素安定同位体の同位体効果2012

    • Author(s)
      菊池奈美,川島洋人
    • Organizer
      大気環境学会年会
    • Place of Presentation
      神奈川県横浜市(神奈川大学)
    • Related Report
      2012 Research-status Report
  • [Remarks] 川島・発生源解析チームのHP

    • URL

      http://www.akita-pu.ac.jp/system/mse/ie/khiroto/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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