Bioinformatics-based functional analysis of telomeric non-coding RNA
| Project/Area Number |
24650639
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor diagnosis
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
SEIMIYA Hiroyuki 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 部長 (50280623)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | テロメア / 非コードRNA / がん / バイオインフォマティクス / 分化 |
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| Research Abstract |
Telomeres are specialized structures that stabilize the genome at the ends of linear chromosomes. Recently, it has been reported that telomeric DNAs are transcribed to non-coding RNAs called TERRA. Since the precise importance of TERRA remains unknown, here we investigated the function of TERRA especially in human cancer cells. As the results, we found that cancer cells with more TERRA expression decrease the expression of protein X, which regulates the growth signal elicited by tyrosine phosphorylation. Telomere elongation enhanced TERRA expression and induced differentiation of cancer cells. These results suggest that TERRA regulates its expression upon the change in telomeric structure and modulates the cancer malignancy. These observations may be utilized for cancer diagnosis and therapeutics.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Telomere length influences cancer cell differentiation in vivo.2013
Author(s)
Hirashima, K., Migita, T., Sato, S., Muramatsu, Y., Ishikawa, Y., Seimiya, H.
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Journal Title
Molecular and Cellular Biology
Volume: 33
Pages: 2988-2995
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibition of ATP Citrate Lyase Induces an Anticancer Effect via Reactive Oxygen Species: AMPK as a Predictive Biomarker for Therapeutic Impact.2013
Author(s)
Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
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Journal Title
Am J Pathol
Volume: 182
Pages: 1800-1810
DOI
Related Report
Peer Reviewed
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[Journal Article] Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb2012
Author(s)
Miyazaki T, Pan Y, Joshi K, Purohit D, Hu B, Demir H, Mazumder S, Okabe S, Yamori T, Viapiano M, Shin-Ya K, Seimiya H, Nakano I.
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Journal Title
Clin Cancer Res
Volume: 18(5)
Pages: 1268-1280
DOI
Related Report
Peer Reviewed
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