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Bioinformatics-based functional analysis of telomeric non-coding RNA

Research Project

Project/Area Number 24650639
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Tumor diagnosis
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

SEIMIYA Hiroyuki  公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 部長 (50280623)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsテロメア / 非コードRNA / がん / バイオインフォマティクス / 分化
Research Abstract

Telomeres are specialized structures that stabilize the genome at the ends of linear chromosomes. Recently, it has been reported that telomeric DNAs are transcribed to non-coding RNAs called TERRA. Since the precise importance of TERRA remains unknown, here we investigated the function of TERRA especially in human cancer cells. As the results, we found that cancer cells with more TERRA expression decrease the expression of protein X, which regulates the growth signal elicited by tyrosine phosphorylation. Telomere elongation enhanced TERRA expression and induced differentiation of cancer cells. These results suggest that TERRA regulates its expression upon the change in telomeric structure and modulates the cancer malignancy. These observations may be utilized for cancer diagnosis and therapeutics.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (39 results)

All 2014 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (21 results) (of which Invited: 13 results) Book (3 results) Remarks (2 results)

  • [Journal Article] TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation2014

    • Author(s)
      Ohishi, T., Muramatsu, Y., Yoshida, H., Seimiya, H.
    • Journal Title

      Mol Cell Biol

      Volume: (in press) Issue: 13 Pages: 2464-2478

    • DOI

      10.1128/mcb.00161-14

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.2014

    • Author(s)
      Ohishi T, Muramatsu Y, Yoshida H, Seimiya H
    • Journal Title

      Mol Cell Biol

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells.2014

    • Author(s)
      5.Migita T, Okabe S, Ikeda K, Igarashi S, Sugawara S, Tomida A, Soga T, Taguchi R, Seimiya H.
    • Journal Title

      Int J Cancer.

      Volume: 135 Issue: 1 Pages: 37-47

    • DOI

      10.1002/ijc.28652

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomere length influences cancer cell differentiation in vivo.2013

    • Author(s)
      Hirashima K, Migita T, Sato S, Muramatsu Y, Ishikawa Y, Seimiya H
    • Journal Title

      Mol Cell Biol

      Volume: 33 Issue: 15 Pages: 2988-2995

    • DOI

      10.1128/mcb.00136-13

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand.2013

    • Author(s)
      Iida, K.
    • Journal Title

      Molecules

      Volume: 18 Issue: 4 Pages: 4328-4341

    • DOI

      10.3390/molecules18044328

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligands2013

    • Author(s)
      Keisuke Iida, Gen Tsubouchi, Takahiro Nakamura, Satoki Majima, Hiroyuki Seimiya, and Kazuo Nagasawa
    • Journal Title

      Med. Chem. Commun.

      Volume: 4 Issue: 1 Pages: 260-264

    • DOI

      10.1039/c2md20234d

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.2013

    • Author(s)
      Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.
    • Journal Title

      Cancer Sci.

      Volume: 104(3) Issue: 3 Pages: 360-368

    • DOI

      10.1111/cas.12071

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact2013

    • Author(s)
      Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
    • Journal Title

      Am J Pathol.

      Volume: 182 Issue: 5 Pages: 1800-1810

    • DOI

      10.1016/j.ajpath.2013.01.048

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Caged Ligand for a Telomeric G-Quadruplex2012

    • Author(s)
      T.Nakamura, K.Iida, M.Tera, K.Shin-ya, H.Seimiya, K.Nagasawa
    • Journal Title

      ChemBioChem

      Volume: Vol.13 Issue: 6 Pages: 774-777

    • DOI

      10.1002/cbic.201200013

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.2012

    • Author(s)
      Deardorff MA
    • Journal Title

      Nature

      Volume: 489(7415) Issue: 7415 Pages: 313-7

    • DOI

      10.1038/nature11316

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.2012

    • Author(s)
      Ha, G.H.
    • Journal Title

      Cell Death Differ

      Volume: 19 Issue: 2 Pages: 321-332

    • DOI

      10.1038/cdd.2011.101

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells.2012

    • Author(s)
      Kawahara, T.
    • Journal Title

      J Antibiot

      Volume: 65 Issue: 7 Pages: 373-375

    • DOI

      10.1038/ja.2012.32

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb2011

    • Author(s)
      Miyazaki T, Pan Y, Joshi K, Purohit D, Hu B, Demir H, Mazumder S, Okabe S, Yamori T, Viapiano M, Shin-Ya K, Seimiya H, Nakano I
    • Journal Title

      Clin Cancer Res

      Volume: 18(5) Issue: 5 Pages: 1268-1280

    • DOI

      10.1158/1078-0432.ccr-11-1795

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Telomeres and G-quadruplexes as targets for cancer therapy.2014

    • Author(s)
      Seimiya, H.
    • Organizer
      Kangwon National University Research Seminar
    • Place of Presentation
      Gangwon-Do, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] テロメア配列はヒトがん細胞の遺伝子発現を制御する2013

    • Author(s)
      平島匡太郎、清宮啓之
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Telomere length influences cancer cell differentiation in vivo2013

    • Author(s)
      Seimiya H.
    • Organizer
      The 3rd GDRI French Japanese Cancer Meeting
    • Place of Presentation
      Toulouse, France
    • Year and Date
      2013-11-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 抗がん剤探索アプローチの変遷と最近の話題2013

    • Author(s)
      清宮啓之
    • Organizer
      第72回日本癌学会学術総会モーニングレクチャー
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] TRF1 ensures proper chromosome segregation in mitosis2013

    • Author(s)
      Seimiya, H., Ohishi, T., Muramatsu, Y.
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Telomeres & Telomerase
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2013-05-02
    • Related Report
      2013 Final Research Report
  • [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation2013

    • Author(s)
      Seimiya, H.
    • Organizer
      1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] TRF1 ensures proper chromosome segregation in mitosis.2013

    • Author(s)
      Seimiya, H
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Telomeres & Telomerase
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] グアニン4重鎖リガンドによる神経膠腫幹細胞のターゲティング2013

    • Author(s)
      清宮啓之
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] G4リガンドによるがん幹細胞のターゲティング2013

    • Author(s)
      清宮啓之
    • Organizer
      第47回愛媛大学分子病態医学セミナー
    • Place of Presentation
      松山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Targeted therapy of glioma stem cells with G-quadruplex ligands.2013

    • Author(s)
      Seimiya, H
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 抗がん剤探索アプローチの変遷と最近の話題2013

    • Author(s)
      清宮啓之
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Telomere length influences cancer cell differentiation in vivo.2013

    • Author(s)
      Seimiya, H
    • Organizer
      3rd GDRI French Japanese Cancer Meeting
    • Place of Presentation
      Toulouse, France
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Targeting glioma stem cells by G-quadruplex ligands2013

    • Author(s)
      Seimiya, H.
    • Organizer
      9th AACR-JCA Joint Conference: Breakthroughs in Basic and Translational Cancer Research
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] テロメア長が腫瘍内遺伝子発現に及ぼす影響2012

    • Author(s)
      平島匡太郎、右田敏郎、佐藤重男、石川雄一、清宮啓之
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation2012

    • Author(s)
      Seimiya, H., Ohishi, T., Muramatsu Y.
    • Organizer
      EMBO Conference on Telomeres and the DNA Damage Response
    • Place of Presentation
      L'Isle sur la Sorgue, France
    • Related Report
      2013 Final Research Report
  • [Presentation] がん研究基礎セミナー「新薬の原石をもとめて〜抗がん剤・化合物スクリーニング〜」2012

    • Author(s)
      清宮啓之
    • Organizer
      平成24年度がん若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Regulation of chromosome segregation by a telomeric protein2012

    • Author(s)
      Seimiya, H.
    • Organizer
      The 11th Korea-Japan-Germany Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gyeongju, Korea
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Invited
  • [Presentation] 新薬の原石をもとめて ~抗がん剤・化合物スクリーニング~2012

    • Author(s)
      Seimiya, H.
    • Organizer
      平成24年度がん若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Targeting glioma stem cells by G-quadruplex ligands2012

    • Author(s)
      Seimiya, H.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation2012

    • Author(s)
      Seimiya, H.
    • Organizer
      EMBO Conference on Telomeres and the DNA Damage Response
    • Place of Presentation
      L’Isle sur la Sorgue, France
    • Related Report
      2012 Research-status Report
  • [Presentation] Targeting glioma stem cells by G-quadruplex ligands2012

    • Author(s)
      Seimiya, H.
    • Organizer
      The 2nd Japanese-French Cancer Workshop
    • Place of Presentation
      徳島
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] ノーベル賞をもたらしたテロメア研究と癌の診断・治療応用への期待、Surgery Frontier 202013

    • Author(s)
      清宮啓之
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Final Research Report
  • [Book] 癌細胞の不死化と難治性、臨牀と研究902013

    • Author(s)
      清宮啓之
    • Publisher
      大道学館出版部
    • Related Report
      2013 Final Research Report
  • [Book] テロメアの維持と細胞の分裂寿命、「がん増殖と悪性化の分子機構」2012

    • Author(s)
      清宮啓之(編者:宮澤恵二・伊東進)
    • Publisher
      化学同人
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.jfcr.or.jp/chemotherapy/department/molecular_biotherapy/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.jfcr.or.jp/chemotherapy/department/molecular_biotherapy/index.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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