An attempt to develop novel anti-cancer agents through fusion of the cancer stem cell hypothesis and mitochondrial metabolism study
Project/Area Number |
24650644
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Clinical oncology
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Research Institution | Yamagata University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
SATO Atsushi 山形大学, 医学部, 助教 (30455901)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 抗がん物質探索 / cancer-initiating cells / oxidative metabolism / mitochondria |
Research Abstract |
The aim of this project is to test the working hypothesis that Warburg effect plays a critical role in the maintenance of cancer stem cells in various intractable human cancers including malignant brain tumors. The results of a series of experiments revealed that a compound with a mitochondrial respiration-promoting effect inhibits the stemness of cancer stem cells derived from intractable human cancers including malignant brain tumors. The results suggest the possibility that Warburg effect may represent a potential target for cancer stem cell-directed therapy.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression2014
Author(s)
Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Int J Oncol
Volume: 44
Pages: 591-599
Related Report
Peer Reviewed
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[Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012
Author(s)
Sato A, Sunayama J, Okada M, Watanabe E, Seino S, Shibuya K, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Stem Cells Transl Med
Volume: 1
Pages: 811-824
Related Report
Peer Reviewed
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[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012
Author(s)
Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Sci Rep
Volume: 2
Pages: 516-516
Related Report
Peer Reviewed
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[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012
Author(s)
Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Sci Rep
Volume: 2
Issue: 1
Pages: 516-516
DOI
Related Report
Peer Reviewed
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