Analysis of Cenp-A and HJURP at damage sites
| Project/Area Number |
24651047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Cenp-A / クロマチン / プロテアソーム / セントロメア / 損傷修復 |
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| Research Abstract |
It has been reported that Cenp-A, a centromere-specific histone, is also found transiently at DNA damage sites.We isolated a mutant, rpt3-1, in which distribution of Cenp-A is abnormal. Interestingly, the mutant is sensitive to DNA damaging agent.These results would suggest that Rpt3 is responsible for removal of Cenp-A from chromatin at proper timing. A part of these results will be published in Nature Communications.
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Report
(3 results)
Research Products
(4 results)
