Structure analysis of non-crystalline particles with sub-micrometer dimensions using X-ray free electron laser
Project/Area Number |
24654140
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Biophysics/Chemical physics
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | コヒーレントX線回折イメージング / X線自由電子レーザー / 三次元再構成 / 非結晶粒子 / ナノ構造 / シミュレーション / 計算物理学 / リボソーム / 位相問題 / 立体構造解析 / 分子動力学シミュレーション / 生体分子水和 / 構造因子 / 氷包埋 |
Research Abstract |
Coherent X-ray diffraction imaging is a lens-less imaging technique that can visualize the structures of non-crystalline particles with micro- to sub-micrometer dimensions in particular using coherent and intense X-ray pulses provided by X-ray free electron laser. In this research project, we developed theories on three-dimensional images of non-crystalline particles and data processing techniques toward molecular imaging in the future.
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Report
(3 results)
Research Products
(86 results)
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[Journal Article] Single-shot 3D structure determination of nanocrystals with femtosecond X-ray free electron laser pulses2014
Author(s)
R. Xu, H. Jiang, C. Song, J. A. Rodriguez, Z. Huang, C.-C. Chen, D. Nam, J. Park, M. Gallagher-Jones, S. Kim, S. Kim, A. Suzuki, Y. Takayama, T. Oroguchi, Y. Takahashi, J. Fan, Y. Zou, T. Hatsui, Y. Inubushi, T. Kameshima, K. Yonekura, K Tono, T. Togashi, T. Sato, M. Yamamoto, M. Nakasako, M. Yabashi, T. Ishikawa and J. Miao
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Journal Title
Nature Communications
Volume: (印刷中)
Related Report
Peer Reviewed
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[Journal Article] KOTOBUKI-1 apparatus for cryogenic coherent X-ray diffraction imaging2013
Author(s)
M. Nakasako, Y. Takayama, T. Oroguchi, Y. Sekiguchi, A. Kobayashi, K. Shirahama, M. Yamamoto*, T. Hikima, K. Yonekura, S. Maki-Yonekura, Y. Kohmura, Y. Inubushi, Y. Takahashi*, A. Suzuki, S. Matsunaga, Y. Inui, K. Tono, T. Kameshima, Y. Joti, and T. Hoshi
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Journal Title
Review of Scientific Instruments
Volume: 84
Issue: 12
Pages: 93705-16
DOI
Related Report
Peer Reviewed
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[Presentation] Cryogenic CXDI experiments for non-crystalline particles using KOTOBUKI-1 apparatus at SACLA: the present status and future plan
Author(s)
M. Nakasako, Y. Takayama, T. Oroguchi, Y. Sekiguchi, A. Kobayashi, K. Shirahama, M. Yamamoto, T. Hikima, K. Yonekura, S. Maki-Yonekura, Y. Kohmura, Y. Inubushi, Y. Takahashi, A. Suzuki, S. Matsunaga, Y. Inui, Y. Ichikawa, H. Kurumizaka, K. Tono, T. Kameshima, Y. Joti, T. Hoshi
Organizer
6-th Workshop on FEL Science
Place of Presentation
Tainan, Taiwan
Related Report
Invited
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[Presentation] Coherent X-ray diffraction imaging of non-crystalline particles with sub-micrometer dimensions
Author(s)
M. Nakasako, Y. Takayama, T. Oroguchi, Y. Sekiguchi, A. Kobayashi, K. Shirahama, M. Yamamoto, T. Hikima, K. Yonekura, S. Maki-Yonekura, Y. Kohmura, Y. Inubushi, Y. Takahashi, A. Suzuki, S. Matsunaga, Y. Inui, Y. Ichikawa, H. Kurumizaka, K. Tono, T. Kameshima, Y. Joti, T. Hoshi
Organizer
Modeling biomolecular systems in cellular environment
Place of Presentation
kyoto, Japan
Related Report
Invited
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[Presentation] KOTOBUKI-1 apparatus for cryogenic coherent X-ray diffraction imaging at SPring-8 and SACLA
Author(s)
M. Nakasako, Y. Takayama, T. Oroguchi, Y. Sekiguchi, A. Kobayashi, K. Shirahama, M. Yamamoto, T. Hikima, K. Yonekura, S. Maki-Yonekura, Y. Kohmura, Y. Inubushi, Y. Takahashi, A. Suzuki, S. Matsunaga, Y. Inui, K. Tono, T. Kameshima, Y. Joti, T. Hoshi
Organizer
The 7-th Asia Oceania Forum for Synchrotron Radiation Research
Place of Presentation
Himeji, Japan
Related Report
Invited
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[Presentation] Humidity-controlled preparation of frozen-hydtrated biological samples for cryogenic coherent X-ray diffraction imaging using XFEL
Author(s)
高山裕貴, 中迫雅由, 苙口友隆, 関口優希, 小林周, 山本雅貴, 米倉功治, 引間孝明, 眞木さおり,高橋幸生, 鈴木明大, 松永幸大, 乾弥生, 加藤翔一, 星 貴彦
Organizer
第51回日本生物物理学会年会
Place of Presentation
京都
Related Report
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