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Creation and structure analysis of hierarchical metal-complex-assembled space based on lipid bilyers

Research Project

Project/Area Number 24655052
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Inorganic chemistry
Research InstitutionKyushu University

Principal Investigator

OHBA Masaaki  九州大学, 理学(系)研究科(研究院), 教授 (00284480)

Co-Investigator(Renkei-kenkyūsha) KOSHIYAMA Tomomi  九州大学, 大学院理学研究院, 助教 (30467279)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords金属錯体化学 / 脂質二重層膜 / リポソーム / 親脂質性金属錯体 / 配位高分子 / 金属錯体 / リン脂質
Research Abstract

The research project targeted creating novel "highly-functional chemical reaction field" in which electron transfer, mass transfer and chemical reaction linked. We tried to establish basic technique for creation and structural analysis of "hierarchical metal-complex-assembled space" in which various functional metal complexes were incorporated rationally. In the project, we succeeded in the following points, (1) synthesis of lipophilic ligands and lipophilic metal complexes, (2) incorporation of metal complexes in the inner aqueous space of liposome, (3) incorporation of metal complexes on the liposome surface and (4) structure evaluation of liposome-metal complex composites.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (42 results)

All 2014 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (36 results) (of which Invited: 4 results) Remarks (5 results)

  • [Journal Article] Guest Responsivity of a Two-Dimensional Coordination Polymer Incorporating a Cholesterol-Based Co-Ligand2013

    • Author(s)
      K. Kajitani, T. Koshiyama, A. Hori, R. Ohtani, A. Mishima, K. Torikai, M. Ebine, T. Oishi, M. Takata, S. Kitagawa, M. Ohba
    • Journal Title

      Dalton Trans.

      Volume: 42 Issue: 45 Pages: 15893-15897

    • DOI

      10.1039/c3dt51465j

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 抗生物質チャネルを利用した金属錯体-リポソーム複合体の創成2014

    • Author(s)
      越山友美、本庄正幸、三島章雄、大場正昭
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋、優秀講演賞(学術)受賞, 口頭発表
    • Year and Date
      2014-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Incorporation of Lipophilic Salen Complexes into Liposomes and Expression of Their Functions2014

    • Author(s)
      K. Nakanishi, T. Hatae, T. Koshiyama, M. Ohba
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋 ,口頭発表
    • Year and Date
      2014-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Programmed Functional Space : from Porous Coordination Polymers to Liposome2014

    • Author(s)
      M. Ohba, T. Koshiyama, R. Ohtani, A. Mishima, A. Hori, M. Takata, S. Kitagawa
    • Organizer
      International Symposium on Coordination Programming 2014 (ISCP2014)
    • Place of Presentation
      東京
    • Year and Date
      2014-01-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Incorporation of Lipophilic Salen Complexes into Liposomes and Expression of Their Functions2014

    • Author(s)
      Keita Nakanishi、Tatsuru Hatae、Tomomi Koshiyama、Masaaki Ohba
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗生物質チャネルを利用した金属錯体-リポソーム複合体の創成2014

    • Author(s)
      越山友美、本庄正幸、三島章雄、大場正昭
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 金属配位部位を導入したチャネル型抗生物質を用いた金属錯体の合成2014

    • Author(s)
      淺田 紗成、越山友美、大場正昭
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膜ドメイン構造と金属錯体による光捕集場の構築2014

    • Author(s)
      波多江 達、越山友美、大場正昭
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗生物質チャネルを用いたリポソーム内水相での配位高分子の合成2014

    • Author(s)
      本庄正幸、越山友美、大場正昭
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Programmed Functional Space: from Porous Coordination Polymers to Liposome2014

    • Author(s)
      Masaaki Ohba、Tomomi Koshiyama、Ryo Ohtani、Akio Mishima、Akihiro Hori、Masaki Takata、Susumu Kitagawa
    • Organizer
      、International Symposium on Coordination Programming 2014 (ISCP2014)
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 配位高分子によるリポソーム内水相の機能化2013

    • Author(s)
      越山友美、本庄正幸、大場正昭
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      沖縄, 口頭発表
    • Year and Date
      2013-11-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Construction of a Novel Reaction System using Liposome Space2013

    • Author(s)
      T. Koshiyama, M. Ohba
    • Organizer
      International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
    • Place of Presentation
      仙台
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] リポソーム空間への金属錯体の部位特異的固定化による新規反応場の構築2013

    • Author(s)
      越山友美、岡村朋哉、岩田浩輝、中西契太、波多江達、吉田将己、正岡重行、大場正昭
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      滋賀, 口頭発表
    • Year and Date
      2013-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 配位高分子によるリポソーム内水相の機能化2013

    • Author(s)
      越山友美、本庄正幸、大場正昭
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report
  • [Presentation] 親脂質性 Salen 型錯体の合成とリポソームへの組込み2013

    • Author(s)
      中西契太、波多江 達、越山友美、大場正昭
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report
  • [Presentation] 親脂質性金属錯体とリポソームの複合化による光捕集システムの構築2013

    • Author(s)
      波多江 達、越山友美、大場正昭
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report
  • [Presentation] Construction of a Novel Reaction System using Liposome Space2013

    • Author(s)
      Tomomi Koshiyama、Masaaki Ohba
    • Organizer
      International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
    • Place of Presentation
      Sendai
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Control of Water Oxidation Reaction by Lipophilic Ru Complex-Liposome Composites2013

    • Author(s)
      Koki Iwata、Tatsuru Hatae、Tomomi Koshiyama、Masaaki Ohba
    • Organizer
      International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
    • Place of Presentation
      Sendai
    • Related Report
      2013 Annual Research Report
  • [Presentation] 親脂質性金属錯体とリポソームによる酸素発生触媒場の構築2012

    • Author(s)
      越山友美、岩田浩輝、波多江達、岡村朋哉、吉田将己、正岡重行、大場正昭
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      富山, 口頭発表
    • Year and Date
      2012-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] リポソームを利用した酸素発生触媒場の構築2012

    • Author(s)
      越山友美、岩田浩輝、波多江達、岡村朋哉、吉田将己、正岡重行、大場正昭
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      札幌, 口頭発表
    • Year and Date
      2012-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 親脂質性金属錯体とリポソームの部位特異的複合化による光反応場の構築

    • Author(s)
      波多江 達、岡村朋哉、越山友美、大場正昭
    • Organizer
      第50回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Related Report
      2013 Annual Research Report
  • [Presentation] 親脂質性 Ru 錯体-リポソーム複合体の酸素発生能の制御

    • Author(s)
      岩田浩輝、岡村朋哉、波多江 達、吉田将己、正岡重行、越山友美、大場正昭
    • Organizer
      第50回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Related Report
      2013 Annual Research Report
  • [Presentation] 親脂質性 Schiff 塩基錯体とリポソームの複合化と機能評価

    • Author(s)
      中西契太、波多江 達、岡村朋哉、越山友美、大場正昭
    • Organizer
      第50回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Related Report
      2013 Annual Research Report
  • [Presentation] リポソームを利用した酸素発生触媒場の構築

    • Author(s)
      越山友美、岩田浩輝、波多江達、岡村朋哉、吉田将己、正岡重行、大場正昭
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 親脂質性金属錯体とリポソームによる酸素発生触媒場の構築

    • Author(s)
      越山友美、岩田浩輝、波多江達、岡村朋哉、吉田将己、正岡重行、大場正昭
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
  • [Presentation] リポソーム表面における配位高分子の逐次合成

    • Author(s)
      大谷 亮、犬飼宗弘、大場正昭、北川 進
    • Organizer
      錯体化学会第62回討論会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
  • [Presentation] 逆ミセル法を利用したプルシアンブルー内包リポソームの合成と評価

    • Author(s)
      岡村朋哉、波多江達、越山友美、大場正昭
    • Organizer
      岡村朋哉、波多江達、越山友美、大場正昭
    • Place of Presentation
      佐賀
    • Related Report
      2012 Research-status Report
  • [Presentation] 配位高分子を用いたリポソームのモルフォロジー制御

    • Author(s)
      大谷 亮、犬飼宗弘、大場正昭、北川 進
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      草津
    • Related Report
      2012 Research-status Report
  • [Presentation] 親脂質性シッフ塩基錯体の合成とリポソームへの組み込み

    • Author(s)
      中西契太、波多江達、岡村朋哉、越山友美、大場正昭
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      草津
    • Related Report
      2012 Research-status Report
  • [Presentation] リポソーム空間への金属錯体の部位特異的固定化による新規反応場の構築

    • Author(s)
      越山友美、岡村朋哉、岩田浩輝、中西契太、波多江達、吉田将己、正岡重行、大場正昭
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      草津
    • Related Report
      2012 Research-status Report
  • [Presentation] 親脂質性Ru錯体-リポソーム複合体の酸素発生能

    • Author(s)
      岩田浩輝、岡村朋哉、波多江達、吉田将己、正岡重行、越山友美、大場正昭
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      草津
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂質二分子膜上における膜親和性金属錯体を用いた配位結合ネットワーク形成

    • Author(s)
      大谷 亮、大場正昭、北川 進
    • Organizer
      日本膜学会第34回年会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Guest-Responsivity of a Two-dimensional Coordination Polymer Providing Hydrophobic Sites

    • Author(s)
      Kazuki Kajitani, Ko Yoneda, Tomomi Koshiyama, Ryo Ohtani, Susumu Kitagawa, Masaaki Ohba
    • Organizer
      40th International Conference on Coordination Chemistry
    • Place of Presentation
      Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] Grain Size Dependence of Guest-Responsivity of a Magnetically Bistable Porous Coordination Polymer

    • Author(s)
      Akio Mishima, Ko Yoneda, Ryo Ohtani, Susumu Kitagawa, Tomomi Koshiyama, Ana B. Gaspar, Jose A. Real, Masaaki Ohba
    • Organizer
      40th International Conference on Coordination Chemistry
    • Place of Presentation
      Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] リポソーム外表面への Zn ポルフィリン錯体の固定化による光誘起電子移動系の構築

    • Author(s)
      波多江達、岡村朋哉、越山友美、大場正昭
    • Organizer
      日本化学会西日本大会
    • Place of Presentation
      佐賀
    • Related Report
      2012 Research-status Report
  • [Presentation] 電子移動系の構築を目指したリポソームへの電子伝導体の導入

    • Author(s)
      波多江達、岡村朋哉、越山友美、大場正昭
    • Organizer
      第49回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Related Report
      2012 Research-status Report
  • [Presentation] 金属錯体-膜複合体の表面状態のゼータ電位による評価

    • Author(s)
      岡村朋哉、波多江達、越山友美、大場正昭
    • Organizer
      第49回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.scc.kyushu-u.ac.jp/Sakutaibussei/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 錯体物性化学研究室研究紹介

    • URL

      http://www.scc.kyushu-u.ac.jp/Sakutaibussei/page02.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 錯体物性化学研究室研究業績

    • Related Report
      2013 Annual Research Report
  • [Remarks] 錯体物性化学研究室研究紹介

    • URL

      http://www.scc.kyushu-u.ac.jp/Sakutaibussei/page02.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 錯体物性化学研究室研究業績

    • URL

      http://www.scc.kyushu-u.ac.jp/Sakutaibussei/page03.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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