| Project/Area Number |
24655072
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Analytical chemistry
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| Research Institution | Kanagawa Academy of Science and Technology |
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Principal Investigator |
KAWANO Ryuji 公益財団法人神奈川科学技術アカデミー, 人工細胞膜システムグループ, 研究員 (90401702)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Shuhei 京都大学, 物質-細胞統合システム拠点, 准教授 (90452276)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 脂質二分子膜 / 膜タンパク質 / MEMS / 金属錯体 / 配位高分子 / 一分子計測 / MOP / ナノポア |
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| Research Abstract |
This project proposes a strategy for single molecule detection using a synthetic metal-organic cage embedded into a channel protein. A single molecule detection based on biological nanopore, such as pore-forming proteins, has been studied as a high sensitive biosensor. However, the size of the biological nanopore is difficult to control because of their inherent structure. In this study, we synthesized metal-organic polyhedra which had ~ 0.6 nm nanopore as a nanocage, and we succesflly integrated this synthetic nanopore with an a-hemolysin (biological) nanopore.
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