| Project/Area Number |
24655113
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
ARITA TOSHIHIKO 東北大学, 多元物質科学研究所, 助教 (50423033)
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| Co-Investigator(Kenkyū-buntansha) |
YABU Hiroshi 東北大学, 多元物質科学研究所, 准教授 (40396255)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ナノ医薬品材料 / 超微粒子 / 有機ナノ結晶 / コロイド / 結晶成長 / 過飽和溶解 / 固体分散 |
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| Research Abstract |
This study aimed to solve most of problems of poorly-water-soluble drugs (acceleration of dissolution, reduction of additives, suppression of aggregation and improvement of solid dispersion) by additive-free nano-sizing. By using esculent carbon dioxide as the solvent and applying triboelectric charge as the dispersion force, additive-free nano-sizing (less than 100nm diameter) of poorly-water soluble drugs was achieved. As the result, above mentioned problems have been solved, in addition, supersaturated dissolution (10% excess dissolution to the saturated concentration) of the nano-sized drugs has been found.
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