Development of New Low-molecular-weight Hydrogelators and Their applications to Cell Culture Materials
| Project/Area Number |
24655181
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic industrial materials
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| Research Institution | Shinshu University |
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Principal Investigator |
SUZUKI Masahiro 信州大学, 総合工学系研究科, 准教授 (30334915)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 超分子ハイドロゲル / 細胞培養基材 / L-アミノ酸 / 超分子化学 / ナノファイバー / ハイドロゲル |
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| Research Abstract |
In this work (two years), as one of the applications of low-molecular-weight hydrogelators to biomaterials, we studied the application to the cell culture materials. Using our many hydrogelators, the fundamental researches were performed under the different conditions (such as kinds of amino acids, charge of gelators, and concentrations). The L-lysine-based hydrogelators with a negative charge functioned as the most effective cell culture materials when culturing the fibroblast of mouse; especially, L-lysine-based hydrogelators having a sulfonate and a sulfate were very effective. On the other hand, the caltivation of osteoblast on the hydrogels based on the L-lysine hydrogelators was failed.
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Report
(3 results)
Research Products
(19 results)
