| Project/Area Number |
24657050
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKA Yoshitaka 東京大学, 理学(系)研究科(研究院), 教授 (70143360)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ペプチド / 生殖 / 性行動 / パラログ遺伝子 / トランスジェニック / メダカ / 神経科学 / 生理学 / 脳・神経 / 動物 / 生理活性 |
|---|
| Research Abstract |
There is a general agreement that a whole genome duplication has occurred early during evolution to produce paralogous genes with diversified functions. Functional compensation of a deleted gene by its paralogous gene has been documented for unicellular organisms, but such functional compensation has not been demonstrated for multicellular organisms so far. We have recently found an example of possible functional compensation between the paralogous genes, kiss1 and kiss2, encoding peptides called kisspeptins, which are considered to be involved in the central regulation of reproduction and/or sexual behavior. Here, we attempted at demonstrating experimentally functional compensation mechanisms of kisspeptin genes using state-of-the-art gene knock-out techniques such as TALEN and CRISPR/Cas9, which can be applied to non-model organisms.
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