• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Experimental demonstration of functional compensation among paralogous genes encoding neuropeptides

Research Project

Project/Area Number 24657050
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionThe University of Tokyo

Principal Investigator

OKA Yoshitaka  東京大学, 理学(系)研究科(研究院), 教授 (70143360)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsペプチド / 生殖 / 性行動 / パラログ遺伝子 / トランスジェニック / メダカ / 神経科学 / 生理学 / 脳・神経 / 動物 / 生理活性
Research Abstract

There is a general agreement that a whole genome duplication has occurred early during evolution to produce paralogous genes with diversified functions. Functional compensation of a deleted gene by its paralogous gene has been documented for unicellular organisms, but such functional compensation has not been demonstrated for multicellular organisms so far. We have recently found an example of possible functional compensation between the paralogous genes, kiss1 and kiss2, encoding peptides called kisspeptins, which are considered to be involved in the central regulation of reproduction and/or sexual behavior. Here, we attempted at demonstrating experimentally functional compensation mechanisms of kisspeptin genes using state-of-the-art gene knock-out techniques such as TALEN and CRISPR/Cas9, which can be applied to non-model organisms.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (78 results)

All 2014 2013 2012 Other

All Journal Article (14 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (56 results) (of which Invited: 9 results) Book (3 results) (of which Peer Reviewed: 1 results) Remarks (5 results)

  • [Journal Article] A neural mechanism underlying mating preferences for familiar individuals in medaka fish.2014

    • Author(s)
      Okuyama T, Yokoi S, Abe H, Isoe Y, Suehiro Y, Imada H, Tanaka M, Kawasaki T, Yuba S, Taniguchi Y, Kamei Y, Okubo K, Shimada A, Naruse K, Takeda H, Oka Y, Kubo T, Takeuchi H
    • Journal Title

      Science (New York, N.Y.)

      Volume: 343 Issue: 6166 Pages: 91-94

    • DOI

      10.1126/science.1244724

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Whole brain-pituitary in vitro preparation of the transgenic medaka (Oryzias latipes) as a tool for analyzing the differential regulatory mechanisms of LH and FSH release.2014

    • Author(s)
      Karigo T, Aikawa M, Kondo C, Abe H, Kanda S, Oka Y.
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 2 Pages: 536-547

    • DOI

      10.1210/en.2013-1642

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sexually dimorphic expression of the sex chromosome-linked genes cntfa and polim3a in the medaka brain.2014

    • Author(s)
      Maehiro S, Takeuchi A, Yamashita J, Hiraki T, Kawabata Y, Nakasone K, Hosono K, Usami T, Paul-Prasanth B, Nagahama Y, Oka Y, Okubo K.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 455 Issue: 1 Pages: 113-119

    • DOI

      10.1016/j.bbrc.2014.01.131

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurobiological study of fish brains gives insights into the nature of gonadotropin-releasing hormone 1-3 neurons.2013

    • Author(s)
      Karigo T, Oka Y.
    • Journal Title

      Frontiers in Endocrinology

      Volume: 4 Pages: 177-177

    • DOI

      10.3389/fendo.2013.00177

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical distribution of sex steroid hormone receptors in the brain of female medaka.2013

    • Author(s)
      Buntaro Zempo, Shiaji Kanda, Kataaki Okubo, Yasuhisa Akazome and Yshitaka Oka.
    • Journal Title

      The Journal of Comparative Neurology

      Volume: 521(8) Issue: 8 Pages: 1760-80

    • DOI

      10.1002/cne.23255

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons2013

    • Author(s)
      Umatani, C., Abe, H., and Oka, Y.
    • Journal Title

      Journal of Neurophysiology

      Volume: 109 Issue: 8 Pages: 2354-2363

    • DOI

      10.1152/jn.00145.2012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons2013

    • Author(s)
      Kanda, S., Akazome, Y., Mitani, Y., Okubo, K., and Oka, Y.
    • Journal Title

      PLosOne

      Volume: 8 Issue: 4 Pages: e62776-e62776

    • DOI

      10.1371/journal.pone.0062776

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression and putative function of kisspeptins and their receptors during early development in medaka2013

    • Author(s)
      Hodne, K., Weltzien, F.-A., Oka, Y., and Okubo, K.
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 9 Pages: 3437-3446

    • DOI

      10.1210/en.2013-1065

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Burst generation mediated by cholinergic input in terminal nerve-gonadotrophin releasing hormone neurones of the goldfish2013

    • Author(s)
      Kawai, T., Abe, H., and Oka, Y.
    • Journal Title

      Journal of Physiology-London

      Volume: 591 Issue: 22 Pages: 5509-5523

    • DOI

      10.1113/jphysiol.2013.258343

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary insights into the steroid sensitive kiss1 and kiss2 neurons in the vertebrate brain2012

    • Author(s)
      Kanda, S., and Oka, Y.
    • Journal Title

      Frontiers in Genomic Endocrinology "Estrogenic control of hypothalamic GnRH neurons"

      Volume: 3:28(Article 28) Pages: 1-10

    • DOI

      10.3389/fendo.2012.00028

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dopaminergic neuromodulation of synaptic transmission between mitral and granule cells in the teleost olfactory bulb2012

    • Author(s)
      Kawai T, Abe H, Oka Y
    • Journal Title

      Journal of Neurophysiology

      Volume: 107(5) Issue: 5 Pages: 1313-1324

    • DOI

      10.1152/jn.00536.2011

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Steroid sensitive kiss2 neurones in the goldfish : evolutionary insights in to the duplicate kisspeptin gene-expressing neurones2012

    • Author(s)
      Kanda S, Karigo T, Oka Y
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 24 Issue: 6 Pages: 1-10

    • DOI

      10.1111/j.1365-2826.2012.02296.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Time-of-day dependent changes in GnRH1 neuronal activities and gonadotropin mRNA expression in a daily spawning fish, medaka2012

    • Author(s)
      Karigo, T., Kanda, S., Abe, H., Okubo, K., and Oka, Y.
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 7 Pages: 3394-3404

    • DOI

      10.1210/en.2011-2022

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Female-specific target sites for both oestrogen and androgen in theteleost brain.2012

    • Author(s)
      Hiraki T, Takeuchi A, Tsumaki T, Zempo B, KandaS, Oka Y, Nagahama Y, Okubo K.
    • Journal Title

      Proceedings of the Royal Society B Biological Sciences

      Volume: 279 Issue: 1749 Pages: 5014-5023

    • DOI

      10.1098/rspb.2012.2011

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Identification of a novel transglutaminase gene is differentially expressed between the sexes in the medaka brain2014

    • Author(s)
      Maehiro, S., Oka, Y., Okubo, K.
    • Organizer
      The 7th AOSCE (The Asia and Oceania Society for the Comparative Endocrinology) Intercongress
    • Place of Presentation
      Keelung, Taiwan
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of a novel transglutaminase gene is differentially expressed between the sexes in the medaka brain2014

    • Author(s)
      Maehiro, S., Oka, Y., Okubo, K.
    • Organizer
      The 7th AOSCE
    • Place of Presentation
      Keelung, 台湾
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脊椎動物キスペプチン神経系の進化と未知の機能2013

    • Author(s)
      神田真司、岡良隆
    • Organizer
      東京大学大気海洋研究所共同利用研究集会
    • Place of Presentation
      柏
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Morphological analysis of the early development of GnRH neuron systems in the EGFP-expressing transgenic medaka lines2013

    • Author(s)
      Takahashi, A., Islam, S., Akazome, Y., Abe, H., Okubo, K., Oka, Y.
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience 2013
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] Neurobiological analysis of dopaminergic inhibition in the HPG axis regulation2013

    • Author(s)
      Karigo, T., Oka, Y.
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience 2013
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] 生殖の中枢制御に関わるペプチドニューロン系の研究2013

    • Author(s)
      岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 生殖・性行動調節にかかわる脳部位における性差2013

    • Author(s)
      岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 終神経GnRHニューロンが視覚神経回路に及ぼす作用の解析2013

    • Author(s)
      馬谷千恵、阿部秀樹、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] メダカの配偶者選択の分子神経基盤2013

    • Author(s)
      奥山輝大、横井佐織、阿部秀樹、磯江泰子、末廣勇司、今田はるか、島田敦子、川崎隆史、弓場俊輔、谷口善仁、亀井保博、田中実、成瀬清、武田洋幸、岡良隆、久保健雄、竹内秀明
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] RFRPニューロンの自発活動とGnRH1ニューロン発火抑制に関する電気生理学的解析2013

    • Author(s)
      貝瀬峻、神田真司、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] 性ステロイド感受性を示すKiss1ニューロンの電気生理学的解析2013

    • Author(s)
      長谷部政治、神田真司、島田洋之、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] GnRH neurons involved in central regulation of reproduction and reproductive behavior2013

    • Author(s)
      Oka, Y.
    • Organizer
      2013 Gordon Research Conference, Neuroethology : Behavior, Evolution & Neurobiology; Networks, Circuits, and Modules, Mount Snow Resort, West Dover, VT
    • Place of Presentation
      USA
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 生殖の中枢制御の鍵を握るキスペプチンとその受容体GPR54を発現するニューロンへの新たな生理学的アプローチ2013

    • Author(s)
      岡良隆
    • Organizer
      第10回GPCR研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] Functional and evolutionary diversity of vertebrate kisspeptin neuron systems脊椎動物キスペプチン神経系の進化と多様な機能2013

    • Author(s)
      Kanda, S. and Oka, Y.
    • Organizer
      Hiroshi and Aya Irisawa Memorial Award Symposium, The 90th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 脊椎動物キスペプチン神経系の進化と未知の機能2013

    • Author(s)
      神田真司、岡良隆
    • Organizer
      東京大学大気海洋研究所共同利用研究集会
    • Place of Presentation
      柏、千葉
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] GnRH neurons involved in central regulation of reproduction and reproductive behavior2013

    • Author(s)
      Oka, Y.
    • Organizer
      2013 Gordon Research Conference
    • Place of Presentation
      West Dover,合衆国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 終神経GnRH ニューロンが視覚神経回路に及ぼす作用の解析2013

    • Author(s)
      馬谷千恵、阿部秀樹、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] RFRP ニューロンの自発活動とGnRH1 ニューロン発火抑制に関する電気生理学的解析2013

    • Author(s)
      貝瀬峻、神田真司、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 性ステロイド感受性を示すKiss1 ニューロンの電気生理学的解析2013

    • Author(s)
      長谷部政治、神田真司、島田洋之、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neurobiological analysis of dopaminergic inhibition in the HPG axis regulation.2013

    • Author(s)
      Karigo, T., Oka, Y.
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience 2013
    • Place of Presentation
      San Diego,合衆国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Morphological analysis of the early development of GnRH neuron systems in the EGFP-expressing transgenic medaka lines2013

    • Author(s)
      Takahashi, A., Islam, S., Akazome, Y., Abe, H., Okubo, K., Oka, Y.
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience 2013
    • Place of Presentation
      San Diego,合衆国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional and evolutionary diversity of vertebrate kisspeptin neuron systems2013

    • Author(s)
      Kanda, S and Oka, Y.
    • Organizer
      Hiroshi and Aya Irisawa Memorial Award Symposium, The 90th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ガラニン受容体を介したキスペプチン誘導性黄体形成ホルモン分泌の抑制的調節機構2012

    • Author(s)
      家田菜穂子、上野山賀久、山本恵理、岡良隆、杉原稔、小野幸輝、諏訪牧子、石井寛高、加藤昌克、尹成珠、佐久間康夫、前多敬一郎、束村博子
    • Organizer
      GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] gpr54-1-EGFP Transgenic Medaka - a New Approach towards the Understanding of Novel Functions of Kisspeptin Neurons2012

    • Author(s)
      Kanda, S., Nakajo, M., Lee, J., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Embryonic Expression and Function of Kisspeptins and their Receptors in a Teleost Fish, medaka2012

    • Author(s)
      Okubo, K., Hodne, K., Kanda, S., Shimada, H., Oka, Y., Weltzien, F.A.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Electrophysiological and Morphological Analysis of Kiss1 Neurons in Trasgenic Medaka, Oryzias latipes2012

    • Author(s)
      Shimada, H., Kanda, S., Akazome, Y., Abe, H., Okubo, K., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of Kisspeptins on LH Secretion and GnRH1 Neuronal Activities in Goldfish and Medaka2012

    • Author(s)
      Karigo, T., Uenoyama, Y., Oishi, S., Fujii, N., Mitani, Y., Kanda, S., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Generation of kiss1 Knockout Medaka using Efficient New Genetic Tools, TALENs2012

    • Author(s)
      Takahashi, A., Kanda, S., Akazome, Y., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Steroid Sensitive Hypothalamic Kiss1 Neurons in Medaka do not Co-express NKB or DYN2012

    • Author(s)
      Zempo, B., Kanda, S., Akazome, Y., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Kiss2 may Activate Receptors for Neuropeptide FF (NPFF) / RF Amide Related Peptide (RFRP) in Medaka2012

    • Author(s)
      Akazome, Y., Yamamoto, E., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibitory Regulation of GnRH3 Neurons by RFRP Neurons in Medaka2012

    • Author(s)
      Nakane, R., Kanda, S., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Neuroanatomical evidence for direct kisspeptin regulation of vasotocin and isotocin neurons2012

    • Author(s)
      S. Kanda, Y. Oka
    • Organizer
      The 42th Annual Meeting of the Society for Neuroscience 2012
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Neuropeptide RFRP inhibits the pacemaker activity of extrahypothalamic GnRH neurons2012

    • Author(s)
      C. Umatani, H. Abe, Y. Oka
    • Organizer
      The 42th Annual Meeting of the Society for Neuroscience 2012
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] メダカにおける、メスの配偶者選択行動の神経機構2012

    • Author(s)
      奥山輝大、横井佐織、阿部秀樹、末廣勇司、今田はるか、田中実、川崎隆史、谷口善仁、亀井保博、島田敦子、成瀬清、武田洋幸、岡良隆、久保健雄、竹内秀明
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] RFRPによる終神経GnRHニューロン発火活動抑制作用の解析2012

    • Author(s)
      馬谷千恵、阿部秀樹、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 終神経GnRHニューロンにおけるコリン作動性入力を介したバースト活動の誘起2012

    • Author(s)
      河合喬文、阿部秀樹、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 終神経GnRHペプチドニューロン細胞塊におけるGnRHニューロン間結合様式2012

    • Author(s)
      阿部秀樹、西川穂高、末次翔太、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 生殖中枢制御に対するドーパミンを介した抑制作用に関する神経生物学的解析2012

    • Author(s)
      苅郷友美、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 絶食によるメダカ視床下部NPYニューロンのNPY mRNA発現変動2012

    • Author(s)
      北原翔一、神田真司、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] キスペプチン受容体発現ニューロンのGFP標識による未知のキスペプチン機能の探索2012

    • Author(s)
      神田真司、李惇馥、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 生殖中枢制御に対するドーパミンを介した抑制作用に関する神経生物学的解析2012

    • Author(s)
      苅郷友美、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学、大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 絶食によるメダカ視床下部NPYニューロンのNPY mRNA発現変動2012

    • Author(s)
      北原翔一、神田真司、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学、大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] キスペプチン受容体発現ニューロンのGFP標識による未知のキスペプチン機能の探索2012

    • Author(s)
      神田真司、李惇馥 、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学、大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] メダカにおける、メスの配偶者選択行動の神経機構2012

    • Author(s)
      奥山輝大、横井佐織、阿部秀樹、末廣勇司、今田はるか、田中実、川崎隆史、谷口善仁、亀井保博、島田敦子、成瀬清、武田洋幸、岡良隆、久保健雄、竹内秀明
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] RFRPによる終神経GnRHニューロン発火活動抑制作用の解析2012

    • Author(s)
      馬谷千恵、阿部秀樹、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 終神経GnRHニューロンにおけるコリン作動性入力を介したバースト活動の誘起2012

    • Author(s)
      河合喬文、阿部秀樹、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 終神経GnRHペプチドニューロン細胞塊におけるGnRHニューロン間結合様式2012

    • Author(s)
      阿部秀樹、西川穂高、末次翔太、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] gpr54-1-EGFP Transgenic Medaka - a New Approach towards the Understanding of Novel Functions of Kisspeptin Neurons2012

    • Author(s)
      Kanda, S., Nakajo, M., Lee, J., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Embryonic Expression and Function of Kisspeptins and their Receptors in a Teleost Fish, medaka2012

    • Author(s)
      Okubo, K., Hodne, K., Kanda, S., Shimada, H., Oka, Y., Weltzien, F.A.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Electrophysiological and Morphological Analysis of Kiss1 Neurons in Trasgenic Medaka, Oryzias latipes2012

    • Author(s)
      Shimada, H., Kanda, S., Akazome, Y., Abe, H., Okubo, K., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of Kisspeptins on LH Secretion and GnRH1 Neuronal Activities in Goldfish and Medaka.2012

    • Author(s)
      Karigo, T., Uenoyama, Y., Oishi, S., Fujii, N., Mitani, Y., Kanda, S., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Generation of kiss1 Knockout Medaka using Efficient New Genetic Tools, TALENs2012

    • Author(s)
      Takahashi, A., Kanda, S., Akazome, Y., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Steroid Sensitive Hypothalamic Kiss1 Neurons in Medaka do not Co-express NKB or DYN2012

    • Author(s)
      Zempo, B., Kanda, S., Akazome, Y., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Kiss2 may Activate Receptors for Neuropeptide FF (NPFF) / RF Amide Related Peptide (RFRP) in Medaka2012

    • Author(s)
      Akazome, Y., Yamamoto, E., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] Inhibitory Regulation of GnRH3 Neurons by RFRP Neurons in Medaka2012

    • Author(s)
      Nakane, R., Kanda, S., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2012 Research-status Report
  • [Presentation] ガラニン受容体を介したキスペプチン誘導性黄体形成ホルモン分泌の抑制的 調節機構

    • Author(s)
      家田菜穂子、上野山賀久、山本恵理、岡良隆、杉原稔、小野幸輝、諏訪牧子、石井寛高、加藤昌克、尹成珠、佐久間康夫、前多敬一郎、束村博子
    • Organizer
      GPCR研究会
    • Place of Presentation
      日本科学未来館、東京
    • Related Report
      2012 Research-status Report
  • [Book] Structure, synthesis, and phylogeny of kisspeptin and its receptor. In : Kisspeptin Signaling in Reproductive Biology(ed. by A. Kauffman and J. Smith), Chapter 22013

    • Author(s)
      Kanda, S., and Oka, Y.
    • Publisher
      Springer Verlag, New York
    • Related Report
      2013 Final Research Report
  • [Book] Structure, synthesis, and phylogeny of kisspeptin and its receptor. In: " Kisspeptin Signaling in Reproductive Biology " (ed. by A. Kauffman and J. Smith), Chapter 2, Adv Exp Med Biol.2013

    • Author(s)
      Kanda, S., and Oka, Y.
    • Journal Title

      Kisspeptin Signaling in Reproductive Biology

      Volume: 784 Pages: 9-26

    • Publisher
      Springer Verlag, New York(doi:10.1007/978-1-4614-6199-9_2 査読有)
    • DOI

      10.1007/978-1-4614-6199-9_2

    • ISBN
      9781461461982, 9781461461999
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Book] Structure, synthesis, and phylogeny of kisspeptin and its receptor2013

    • Author(s)
      Kanda, S., and Oka, Y.
    • Total Pages
      18
    • Publisher
      Springer Verlag
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/naibunpi/lab.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 生体情報学研究室

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/naibunpi/lab.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院理学系研究科生物科学専攻

    • URL

      http://www.bs.s.u-tokyo.ac.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 生体情報学研究室

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/naibunpi/lab.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 東京大学大学院理学系研究科・理学部

    • URL

      http://www.s.u-tokyo.ac.jp/people/index.php/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi