Crosstalk between citrate sycle and gene expression system and inflammation and cancer
Project/Area Number |
24657092
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
|
Research Institution | Hiroshima University |
Principal Investigator |
KAMATA hideaki 広島大学, 医歯薬保健学研究院, 准教授 (10233925)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | HIF1 / NF-kB / クエン酸回路 / HIF-1a / 酸素 / 翻訳 / 代謝 / クエン酸 / HIF1-α / ROS / 炎症 / 発がん |
Outline of Final Research Achievements |
Cross talk between metabolites of citrate cycle and transcription factors including HIF-1α and NF-κB play essential role in inflammation and cancer. HIF-1α activity is regulated by protein degradation through ubiquitin proteasome system and by NF-κB-mediated transcription. Here we found that citrate suppressed translation of HIF-1α in a cell type-specific manner, and inhibited HIF-1α-mediated gene expression.
|
Report
(4 results)
Research Products
(29 results)
-
[Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015
Author(s)
Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
-
Journal Title
Nature communications
Volume: 6
Issue: 1
Pages: 6780-6780
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.2015
Author(s)
Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yasuka Matsunaga, Haruya Ohno, Masayasu Yoneda, Hideaki Kamata, Takanori Shinjo, Misaki Iwashita, Fusanori Nishimura, and Tomoichiro Asano
-
Journal Title
Am. J. Physiol. Gastrointest. Liver Physiol.
Volume: 308
Issue: 2
Pages: 151-158
DOI
Related Report
Peer Reviewed
-
[Journal Article] Lactobacillus casei strain Shirota protects against non-alcoholic steatohepatitis development in a rodent model2013
Author(s)
Okubo H, Sakoda H, Kushiyama A, Fujishiro M, Nakatsu Y, Fukushima T, Matsunaga Y, Kamata H, Asahara T, Yoshida Y, Chonan O, Iwashita M, Nishimura F, Asano T
-
Journal Title
American Journal Physiolgy-Gastrointestinal and Liver Physiogy
Volume: 305
Issue: 12
Pages: 911-918
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development.2013
Author(s)
Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
-
Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 33
Issue: 8
Pages: 1986-1993
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Par14 associates with IRS-1, thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.2013
Author(s)
Zhang J, Nakatsu Y, Sinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T.
-
Journal Title
Journal of Biological Chemistry
Volume: 288
Issue: 28
Pages: 20692-20701
DOI
Related Report
Peer Reviewed
-
[Journal Article] Integrator complex plays anessential role inadipose differentiation2013
Author(s)
Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.
-
Journal Title
Biochemical and Biophysical Research Communications
Volume: 434
Issue: 2
Pages: 197-202
DOI
Related Report
Peer Reviewed
-
[Journal Article] Integrator complex plays anessential role inadipose differentiation2013
Author(s)
Y. Otani, Y. Nakatsu, H. Sakoda, T. Fukushima, M. Fujishiro, A. Kushiyama, H. Okubo, Y. Tsuchiya, H. Ohno, S. Takahashi, F. Nishimura, H. Kamata, H. Katagiri, T. Asano
-
Journal Title
Biochem. Biophys. Res. Commun.
Volume: 434
Pages: 197-202
Related Report
Peer Reviewed
-
-
-
[Journal Article] Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages2012
Author(s)
S. Kumamoto, A. Kushiyama, Y. Nakatsu, H. Sakoda, M. Fujishiro, M. Iwashita, H. Ohno, J. Zhang, Y. Guo, H. Aburatani, H. Kamata, F. Nishimura, and T. Asano
-
Journal Title
Obes. Res. Clin. Pract.
Volume: 6
Pages: 288-297
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-