Analysis of signaling mechanisms for cellular response to low temperature in mammals
| Project/Area Number |
24657140
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
SATOH Takaya 大阪府立大学, 理学(系)研究科(研究院), 教授 (20251655)
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| Co-Investigator(Kenkyū-buntansha) |
TAKENAKA Nobuyuki 大阪府立大学, 大学院理学系研究科, 助教 (20610504)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 低温刺激 / チロシンキナーゼ / ACK1 |
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| Research Abstract |
Body temperature in mammals is kept constant, contributing to the maintenance of stable environment around the cell. However, even in mammals, particular tissues such as skin and trachea are exposed to low temperature under ordinary conditions. Signaling mechanisms for cellular response to low temperature in these tissues remain obscure. In this study, we analyzed these signaling mechanisms, particularly the regulatory mechanisms and physiological function of the protein tyrosine kinase ACK1, in which tyrosine residues become phosphorylated following temperature shift down to 25 dgree in mammalian cultured cells.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells2013
Author(s)
Nozaki, S., Takeda, T., Kitaura, T., Takenaka, N., Kataoka, T., and Satoh, T.
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Journal Title
Cell. Signal
Volume: 25
Issue: 6
Pages: 1361-1371
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice2013
Author(s)
D Ibi, I Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, U. C. Lange, D. J. Adams, M. Azim Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima and K Yamada
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Journal Title
Glia
Volume: 61
Issue: 5
Pages: 679-693
DOI
Related Report
Peer Reviewed
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