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Research on the molecular mechanisms changing taste sensitivity by internal physiological status.

Research Project

Project/Area Number 24658115
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

OKADA Shinji  東京大学, 農学生命科学研究科, 准教授 (50376563)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords味覚 / 栄養 / 食 / トランスクリプトーム
Research Abstract

Internal physiological status such as eating and nutritional status influences taste sensation. It has revealed about this phenomenon that several hormones and small molecules affect the peripheral taste receptor cells directly and modify the sensitivity to tastants. However, many parts of this mechanism remain unknown. Behavioral physiological analyses suggested the differences in taste sensitivity to one tastant between eating and non-eating animals in this study. This study also suggested the differences in gene expression profile of taste bud cells between two eating status. These results suggested that the mechanisms which modify the taste sensitivity by changing the gene expression exist in the peripheral taste receptor cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (16 results) (of which Invited: 1 results) Book (4 results) Remarks (8 results)

  • [Journal Article] Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).2013

    • Author(s)
      Yasuka Tbda, Tomoya Nakagita, Takashi Hayakawa, Shinji Okada, Masataka Narukawa, Hiroo Imai, Yoshiro Ishimaru, Takumi Misaka.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Issue: 52 Pages: 36863-36877

    • DOI

      10.1074/jbc.m113.494443

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] (4,10/10) Influence of a short-term iron-deficient diet on hepatic gene expression profiles in rats2013

    • Author(s)
      Kamei, A., Okada, S., Abe, K.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 6 Pages: e65732-e65732

    • DOI

      10.1371/journal.pone.0065732

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] (7,8,9/10) Differential expression analysis throughout the weaning period in the mouse cerebral cortex2013

    • Author(s)
      Maeda, N., Okada, S., Abe, K., Aizawa, H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 431 Issue: 3 Pages: 437-443

    • DOI

      10.1016/j.bbrc.2012.12.150

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transgenic labeling of higher order neuronal circuits linked to phospholipase C-β2-expressing taste bud cells in medaka fish.2013

    • Author(s)
      家木誉史
    • Journal Title

      Journal of Comparative Neurology

      Volume: 521 Issue: 8 Pages: 1781-1802

    • DOI

      10.1002/cne.23256

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a New IgE-Binding Epitope of Peanut Oleosin That Cross-Reacts with Buckwheat2012

    • Author(s)
      Kobayashi, S., Katsuyama, S., Wagatsuma, T., Okada, S., and Tanabe, S
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 6 Pages: 1182-1188

    • DOI

      10.1271/bbb.120063

    • NAID

      10030818299

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 亜鉛欠乏と味覚障害・食行動異常2012

    • Author(s)
      岡田晋治
    • Journal Title

      生物の科学遺伝

      Volume: 66 Pages: 643-648

    • URL

      http://ci.nii.ac.jp/naid/40019473291

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dietary zinc status reversibly alters both the feeding behaviors of the rats and gene expression patterns in diencephalon2012

    • Author(s)
      Okada, S., Abuyama, M., Yamamoto, R., Kondo, T., Narukawa, M., and Misaka, T
    • Journal Title

      Biofactors

      Volume: 38 Issue: 3 Pages: 203-218

    • DOI

      10.1002/biof.1007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 亜鉛欠乏と味覚障害・食行動異常2012

    • Author(s)
      岡田晋治
    • Journal Title

      生物の科学 遺伝

      Volume: 66 Pages: 643-648

    • Related Report
      2012 Research-status Report
  • [Presentation] 旨味受容体T1R1/T1R3のL-Glu活性を決定する因子の同定2014

    • Author(s)
      戸田安香、中北智哉、岡田晋治、成川真隆、石丸喜朗、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス有郭乳頭における味蕾マーカーとしてのUlex europaeus agglutinin-1の有用性2014

    • Author(s)
      吉本靖東、岡田晋治、山上圭吾、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Related Report
      2013 Final Research Report
  • [Presentation] メダカ味覚受容体T1R1の転写制御配列の取得2014

    • Author(s)
      池永直弥、吉田晃子、家木誉史、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Related Report
      2013 Final Research Report
  • [Presentation] メダカにおける味覚関連遺伝子群の発現様式2014

    • Author(s)
      家木誉史、池永直弥、吉田晃子、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス(神奈川)
    • Related Report
      2013 Final Research Report
  • [Presentation] メダカにおける味覚関連遺伝子群の発現様式2014

    • Author(s)
      家木 誉史、池永 直弥、吉田 晃子、岡田 晋治、三坂 巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      神奈川県 明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカ味覚受容体T1R1の転写制御配列の取得2014

    • Author(s)
      池永 直弥、吉田 晃子、家木 誉史、岡田 晋治、三坂 巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      神奈川県 明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス有郭乳頭における味蕾マーカーとしてのUlex europaeus agglutinin-1の有用性2014

    • Author(s)
      吉本 靖東、岡田 晋治、山上 圭吾、三坂 巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      神奈川県 明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 旨味受容体T1R1/T1R3のL-Glu活性を決定する因子の同定2014

    • Author(s)
      戸田 安香、中北 智哉、岡田 晋治、成川 真隆、石丸 喜朗、三坂 巧
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      神奈川県 明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 短期亜鉛欠乏におけるラットの味嗜好性変化の解析2013

    • Author(s)
      山本遼、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城)
    • Related Report
      2013 Final Research Report
  • [Presentation] 食餌性鉄欠乏ラットにおける味嗜好性の変化2013

    • Author(s)
      幸田理恵、成川真隆、山本遼、岡田晋治、三坂巧
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城)
    • Related Report
      2013 Final Research Report
  • [Presentation] 短期亜鉛欠乏におけるラットの味嗜好性変化の解析2013

    • Author(s)
      山本遼
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 食餌性鉄欠乏ラットにおける味嗜好性の変化2013

    • Author(s)
      幸田理恵
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] Taste system in fish2012

    • Author(s)
      Abe, K., Okada, S. and Misaka, T.
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT 2012)
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Establishment of a new cell-based assay to measure the sweetness intensities of ligands including fluorescent substances2012

    • Author(s)
      Toda, Y., Okada, S., and Misaka, T.
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT 2012)
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2013 Final Research Report
  • [Presentation] Taste system in fish.2012

    • Author(s)
      阿部啓子
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT 2012)
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Establishment of a new cell-based assay to measure the sweetness intensities of ligands including fluorescent substances.2012

    • Author(s)
      戸田安香
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT 2012)
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Research-status Report
  • [Book] 新・櫻井総合食品事典2012

    • Author(s)
      岡田晋治, ら執筆(櫻井芳人監修、荒井綜一・倉田忠男・田島眞編集)
    • Total Pages
      1183
    • Publisher
      同文書院
    • Related Report
      2013 Final Research Report
  • [Book] 食物と栄養学基礎シリーズ7基礎栄養学(吉田勉監修、佐藤隆一郎・加藤久典編)2012

    • Author(s)
      岡田晋治, ら
    • Total Pages
      160
    • Publisher
      学文社
    • Related Report
      2013 Final Research Report
  • [Book] 新・櫻井 総合食品事典2012

    • Author(s)
      岡田晋治
    • Total Pages
      1183
    • Publisher
      同文書院
    • Related Report
      2012 Research-status Report
  • [Book] 食物と栄養学基礎シリーズ7 基礎栄養学2012

    • Author(s)
      岡田晋治
    • Total Pages
      160
    • Publisher
      学文社
    • Related Report
      2012 Research-status Report
  • [Remarks] 小型魚類メダカをモデルとした味の情報伝達・処理に関わる神経回路の標識

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2013/20130415-1.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 旨味受容体T1R1/T1R3のアミノ酸選択性を決定する分子メカニズムの同定

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2013/20130415-1.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京大学大学院農学生命科学究科ILSI Japan寄付講座「機能性食品ゲノミクス」

    • URL

      http://park.itc.u-tokyo.ac.jp/ilsi/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] ILSI Japan寄付講座「機能性食品ゲノミクス」

    • URL

      http://park.itc.u-tokyo.ac.jp/ilsi/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 小型魚類メダカをモデルとした味の情報伝達・処理に関わる神経回路の標識

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2013/20130415-1.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 旨味受容体T1R1/T1R3のアミノ酸選択性を決定する分子メカニズムの同定

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2014/20140109-1.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院農学生命科学研究科応用生命化学専攻生物機能開発化学研究室

    • URL

      http://park.itc.u-tokyo.ac.jp/biofunc/

    • Related Report
      2012 Research-status Report
  • [Remarks] 小型魚類メダカをモデルとした味の情報伝達・処理に関わる神経回路の標識

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2013/20130415-1.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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