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Screening of food factors inducing regulatory B cells

Research Project

Project/Area Number 24658116
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

TOTSUKA Mamoru  東京大学, 農学生命科学研究科, 准教授 (70227601)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords制御性B細胞 / インターロイキン10 / フラボノイド / ケンフェロール / タマリキセチン / 芳香族炭化水素受容体(AhR) / 抗アレルギー / 抗炎症 / 制御性B細胞 / IL-10 / プロバイオティクス / フィトケミカル
Research Abstract

An experimental system screening flavonoids that enhance the differentiation of mouse B cells to regulatory B cells or those activating regulatory B cells was established. Using this system, we found that kaempferol and tamarixetin upregulated interleukin-10 -producing regulatory B cells in the presence of lipopolisaccharides. Oral administration of kaempferol was found to increase the ratio of regulatory B cells in spleens and mesenteric lymph nodes of mice. Kaempferol and tamarixetin showed an antagonistic activity to aryl-hydrocarbon receptor, and the activity was suggested to contribute to the up-regulation of regulatory B cells. This study demonstrates a novel approach to develop anti-allergic and anti-inflammatory functional foods targeting regulatory B cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 Other

All Presentation (12 results) (of which Invited: 3 results)

  • [Presentation] ケンフェロール経口投与による制御性B細胞の分化誘導とデキストラン硫酸ナトリウム(DSS)腸炎の抑制効果2014

    • Author(s)
      葉鎮豪、堀内準矢、薩秀夫、清水誠、戸塚護
    • Organizer
      日本農芸化学会2014年度大会(JSBBA 2014)
    • Place of Presentation
      明治大学(東京)(口頭発表)
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 食品成分によるT細胞・B細胞機能分化の制御2014

    • Author(s)
      戸塚護
    • Organizer
      日本農芸化学会関東支部2013年度第2回支部例会シンポジウム「食品機能研究の最前線」
    • Place of Presentation
      東京農工大学農学部講堂(東京都府中市)(依頼講演)
    • Year and Date
      2014-02-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Oral administration of kaempferol induces IL-10-producing regulatory B cell population and inhibits dextran sulfate sodium-induced colitis2014

    • Author(s)
      Chenhao YEH, Junya HORIUCHI, Hideo SATSU, Makoto SHIMIZU, Mamoru TOTSUKA
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田校舎(神奈川県川崎市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Aryl hydrocarbon receptor deficiency induces regulatory B cell population with IL-10 and IL-27 production2013

    • Author(s)
      Chen-Hao Yeh、Marc Veldhoen、Mamoru Totsuka
    • Organizer
      第42回日本免疫学会学術集会(JSI 2013)
    • Place of Presentation
      幕張メッセ(千葉)(口頭+ポスター発表)
    • Year and Date
      2013-12-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Modulation of T-cell and B-cell functions by dietary polyphenols2013

    • Author(s)
      Mamoru Totsuka
    • Organizer
      2013 Annual Conference of the Korean Society of Nutrition"Inflammation and Nutrition"、Session 5 'Immunity and Inflammation'
    • Place of Presentation
      Millennium Seoul Hilton Hotel, Seoul, Korea
    • Year and Date
      2013-11-08
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] タマリキセチンによる制御性B細胞の分化誘導とその免疫抑制効果2013

    • Author(s)
      葉鎮豪、清水誠、戸塚護
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(宮城県)(口頭発表)
    • Year and Date
      2013-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Aryl hydrocarbon receptor deficiency induces regulatory B cell population with IL-10 and IL-27 production2013

    • Author(s)
      Chen-Hao Yeh, Marc Veldhoen and Mamoru Totsuka
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ケンフェロールによる制御性B細胞の分化誘導とその実験的自己免疫性脳脊髄炎に対する抑制効果2012

    • Author(s)
      葉鎮豪、薩秀夫、清水誠、戸塚護
    • Organizer
      日本食品免疫学会第8回学術大会
    • Place of Presentation
      ヤクルトホール(東京都)(ポスター発表)
    • Year and Date
      2012-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Modulation of T-cell and B-cell functions by dietary polyphenols

    • Author(s)
      Mamoru Totsuka
    • Organizer
      2013 Annual Conference of the Korean Society of Nutrition
    • Place of Presentation
      Millennium Seoul Hilton Hotel, Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 食品成分によるT細胞・B細胞機能分化の制御

    • Author(s)
      戸塚 護
    • Organizer
      日本農芸化学会関東支部2013年度第2回支部例会シンポジウム「食品機能研究の最前線」
    • Place of Presentation
      東京農工大学 農学部講堂(東京都府中市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ケンフェロールによる制御性B 細胞の分化誘導とその実験的自己免疫性脳脊髄炎に対する抑制効果

    • Author(s)
      葉 鎮豪, 薩 秀夫, 清水 誠, 戸塚 護
    • Organizer
      日本食品免疫学会 第8回学術大会
    • Place of Presentation
      ヤクルトホール(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] タマリキセチンによる制御性B細胞の分化誘導とその免疫抑制効果

    • Author(s)
      葉 鎮豪, 清水 誠, 戸塚 護
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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