| Project/Area Number |
24658267
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MATSUDA Hiroshi 東京農工大学, (連合)農学研究科(研究院), 教授 (80145820)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 臨床病理・病態 / 羊水塞栓症 / 動物モデル / トランスレーショナルリサーチ / 疾患モデル動物 / 病理学 / 動物 |
|---|
| Research Abstract |
NC/Tnd mice are widely used for a study on atopic dermatitis as a spontaneous model all over the world, but breeding is difficult and there are some maternal death in the third pregnancy trimester and newborn baby death at the time of the delivery. However, the cause has been unclear. The amniotic fluid embolism which has a serious influence on a perinatal mother's body brings the anaphylactic condition of a patient. Therefore, in this study, we focused on perinatal abnormality occurred in NC/Tnd mice and examined immune status of the mice during pregnancy. As a result, the blood concentration of anaphylatoxin and the platelet activating factor was higher than the standard mice. Results indicate that the Th1 immune responses in pregnant NC/Tnd mice may involve in abnormalities that are noticed during the perinatal period.
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