Regulation of IgA responses against influenza virus
| Project/Area Number |
24659029
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | St. Luke's International University (2014)
The University of Tokyo (2012-2013) |
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Principal Investigator |
IRIMURA Tatsuro 聖路加国際大学, その他部局等, その他 (80092146)
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790)
AINAI Akira 国立感染症研究所, インフルエンザ研究センター, 研究員 (10572133)
DENDA Kaori 聖路加国際大学, 研究センター, 上級研究院 (00313122)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | レクチン / インフルエンザ / 樹状細胞 / 免疫ノグロブリン / ウイルス / 感染症 / 糖鎖 / 免疫学 / 薬学 |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate whether MGL2 is involved in the immune response against influenza virus, particularly IgA responses, in the airway using mice. Mouse-adapted influenza strain, PR8, was administrated into the airways of MGL2-KO and wild-type mice and pathogenesis, cytokine production, and immunoglobulin production were investigated. There was no remarkable differences in MGL2-KO mice. However, in the skin, dendritic cells expressing MGL2 were proven to be responsive for skewing the response toward the Th2-type.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices.2014
Author(s)
Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka T, Hayakawa Y, Nakajima M, Irimura T.
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Journal Title
Biochemical Jornal
Volume: 458(2)
Issue: 2
Pages: 291-9
DOI
Related Report
Peer Reviewed
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[Journal Article] CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.2014
Author(s)
Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K.
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Journal Title
BMC Cancer.
Volume: 14
Issue: 1
Pages: 949-949
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway.2013
Author(s)
Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J.
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Journal Title
Cancer Letters
Volume: 339(1)
Pages: 82-92
Related Report
Peer Reviewed
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[Journal Article] Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.2012
Author(s)
Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M.
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Journal Title
Eur J Immunol.
Volume: 42(4)
Issue: 4
Pages: 936-45
DOI
Related Report
Peer Reviewed
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