| Project/Area Number |
24659029
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | St. Luke's International University (2014)
The University of Tokyo (2012-2013) |
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Principal Investigator |
IRIMURA Tatsuro 聖路加国際大学, その他部局等, その他 (80092146)
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790)
AINAI Akira 国立感染症研究所, インフルエンザ研究センター, 研究員 (10572133)
DENDA Kaori 聖路加国際大学, 研究センター, 上級研究院 (00313122)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | レクチン / インフルエンザ / 樹状細胞 / 免疫ノグロブリン / ウイルス / 感染症 / 糖鎖 / 免疫学 / 薬学 |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate whether MGL2 is involved in the immune response against influenza virus, particularly IgA responses, in the airway using mice. Mouse-adapted influenza strain, PR8, was administrated into the airways of MGL2-KO and wild-type mice and pathogenesis, cytokine production, and immunoglobulin production were investigated. There was no remarkable differences in MGL2-KO mice. However, in the skin, dendritic cells expressing MGL2 were proven to be responsive for skewing the response toward the Th2-type.
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