| Project/Area Number |
24659047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
TANIGUCHI YOSUKE 九州大学, 薬学研究科(研究院), 准教授 (00452714)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ゲノム創薬 / 酸化損傷塩基 / 遺伝子検出 / 認識分子 / 8-oxo-rG / 人工核酸 / oxorG |
|---|
| Research Abstract |
In this study, we developed the novel nucleoside analogues for the recognition of the damage to the nucleic acid in order to establish a new diagnosis of disease based on the stress. 8-Oxo-G is the oxidative damage base of guanine, and it is unknown the properties of it in single-stranded RNA. Thus, the purpose of the present work was developed a sequence specific detection molecules and methods of 8-oxo-rG in RNA. We developed a new synthesis method of RNA-type 8-oxoG. And we found the novel nucleoside analogues, 2-amino-Adap and 2'-OMe-Adap. These analogues could recognize and detect the 8-oxo-rG in RNA.
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