Development of in vitro embryotoxic test for nanomaterials

• Project/Area Number: 24659075
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Osaka University
• Principal Investigator: YOSHIOKA Yasuo 大阪大学, 薬学研究科(研究院), 准教授 (00392308)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ナノマテリアル / 生殖発生毒性 / 安全性 / 発生毒性試験法 / 胎仔培養法

Research Abstract

Recently, research into potential safety of nanomatelials is increasing. However, few studies are examined the embryotoxicity of nanomatelials. Therefore, we had investigated the embryotoxicity of nanomatelials, and revealed that some nanomatelials might have a potential to cause pregnancy complications. To assess more detail embryotoxicity of nanomatelials, we tried to accumulate the basic information for the development of embryotoxicity method of nanomatelials in vitro.

Research Products

• [Presentation] サブナノ白金の母乳移行性に関する安全科学的検討 (2013)
  • Author(s): 野尻奈央, 吉岡靖雄, 森下裕貴, 佐藤宏祐, 田中智大, 角田慎一, 東阪和馬, 堤 康央
  • Organizer: 第40回日本毒性学会学術年会
  • Place of Presentation: 千葉
• [Presentation] Biodistribution analysis of sub-nano platinum focused on the transfer to the breast milk (2013)
  • Author(s): Nojiri N., Yoshioka Y., Morishita Y., Satoh H., Tanaka T., Tsunoda S., Higashisaka K., Tsutsumi Y
  • Organizer: The XIII International Congress of Toxicology 2013
  • Place of Presentation: 韓国
• [Presentation] The analysis of inflammatory response to nano- and sub-nano-silver particles in human macrophage like cells, THP-1 (2013)
  • Author(s): Nishijima N., Yoshioka Y., Hirai T., Takahashi H., Ichihashi K., Tsunoda S., Yoshikawa T., Higashisaka K., Tsutsumi Y.
  • Organizer: The XIII International Congress of Toxicology 2013
  • Place of Presentation: 韓国
• [Presentation] The effect of prenatal exposure to amorphous nanosilica particles on neonatal memory (2013)
  • Author(s): Yuki Morishita
  • Organizer: SOT2013
  • Place of Presentation: アメリカ
• [Presentation] A mechanistic analysis of silica nanoparticle-induced immune-modulating effect in murine dendritic cells (2013)
  • Author(s): Hideki Takahashi
  • Organizer: SOT2013
  • Place of Presentation: アメリカ
• [Presentation] サブナノ素材の妊娠期曝露による胎仔影響の基礎検討 (2012)
  • Author(s): 佐藤宏祐, 吉岡靖雄, 森下裕貴, 野尻奈央, 角田慎一, 鍋師裕美, 吉川友章, 堤康央
  • Organizer: 第39回日本毒性学会学術年会
  • Place of Presentation: 仙台, 宮城
• [Presentation] In vitro evaluation of the embryotoxic potency of amorphous nanosilica (2012)
  • Author(s): Ogura T., Yoshioka Y., Yamashita K., Taira M., Aoyama M., Tsunoda S., Kawabata K., Mizuguchi H., Nabeshi H., Yoshikawa T., Tsutsumi Y.
  • Organizer: The 6^<th> International Conference on Nanotoxicology (Nanotoxicology 2012)
  • Place of Presentation: Beijing, China
• [Presentation] Postnatal effects of prenatal exposure to amorphous nanosilica particles on neonatal cognitive functions (2012)
  • Author(s): Morishita Y., Yoshioka Y., Takao K., Ago Y., Satoh H., Nojiri N., Takuma K., Tsunoda S., Nabeshi H., Yoshikawa T., Matsuda T., Miyakawa T., Tsutsumi Y.
  • Organizer: SETAC Asia/Pacific 2012
  • Place of Presentation: Kumamoto, Japan
• [Presentation] サブナノ白金の妊娠期投与による次世代影響に関する基礎的検討 (2012)
  • Author(s): 森下裕貴
  • Organizer: 第39回日本毒性学会学術年会
  • Place of Presentation: 宮城（仙台国際センター）
• [Presentation] サブナノ素材の妊娠期曝露による胎仔影響の基礎検討 (2012)
  • Author(s): 佐藤宏祐
  • Organizer: 第39回日本毒性学会学術年会
  • Place of Presentation: 宮城（仙台国際センター）
• [Presentation] ナノ銀・サブナノ銀の経鼻ハザード同定 (2012)
  • Author(s): 市橋宏一
  • Organizer: 第39回日本毒性学会学術年会
  • Place of Presentation: 宮城（仙台国際センター）
• [Presentation] In vitro evaluation of the embryotoxic potency of amorphous nanosilica (2012)
  • Author(s): Toshinobu Ogura
  • Organizer: The 6th International Conference on Nanotoxicology
  • Place of Presentation: 中国
• [Presentation] Hazard identification of sub-nano platinum on neonates by intrauterine exposure (2012)
  • Author(s): Hiroyoshi Satoh
  • Organizer: The 6th International Conference on Nanotoxicology
  • Place of Presentation: 中国
• [Presentation] Hazard identification of exposure to sub-nano platinum in lactation period (2012)
  • Author(s): Nao Nojiri
  • Organizer: The 6th International Conference on Nanotoxicology
  • Place of Presentation: 中国
• [Presentation] Postnatal effects of prenatal exposure to amorphous nanosilica particles on neonatal cognitive functions (2012)
  • Author(s): Yuki Morishita
  • Organizer: SETAC Asia/Pacific 2012
  • Place of Presentation: 熊本（ANAホテル熊本）