Developmental mechanisms of viscerosensory neurons

Research Project

Project/Area Number	24659080
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	General anatomy (including Histology/Embryology)
Research Institution	University of Tsukuba
Principal Investigator	SHIGA Takashi 筑波大学, 医学医療系, 教授 (50178860)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Runx転写因子 / 内臓感覚 / 迷走神経 / 細胞分化 / 神経ペプチド / 食道 / RUnx転写因子 / 神経栄養因子 / TRP
Research Abstract	The roles of Runx transcription factor in the development of viscerosensory neurons were examined with special reference to nodose-jugular ganglia complex (NG-JG) and esophagus. Runx1 was expressed in medium- to large-sized neurons in NG-JG. Anaysis using Runx1-deficient mice showed that runx1 inhibits the expression of CGRP in nerve fibers in the esophagus.