| Project/Area Number |
24659162
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Nariaki 大阪大学, 大学院医学系研究科, 教授 (70190402)
KAWAGUCHI Naomasa 大阪大学, 大学院医学系研究科, 准教授 (70224748)
MORI Seizi 大阪大学, 大学院医学系研究科, 助教 (90467506)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | LINC complex / nesprin / laminA/C / SUN1 / SUN2 / nesprin2 / 分子病理 |
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| Research Abstract |
The evaluation of mRNA and protein expression by cellular experiments revealed a decrease in the expression of SUN2 and nesprin 2, and the evaluation of the expression of these proteins by immunostaining of tissue samples revealed a tendency for a decrease in the expression of lamin A/C, SUN1, SUN2, and nesprin 2. Furthermore, results of the statistical analysis showed that lamin A/C and nesprin 2 contributed to the exacerbation of breast cancer. Previous cellular-level studies have also reported the existence of a relationship between decreased lamin A/C expression and the exacerbation of breast cancer. These evidences suggest that the expression of LINC complex proteins tends to be decreased in patients with breast cancer and that a decreased expression of lamin A/C and nesprin 2, in particular, is involved in the exacerbation of breast cancer.
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