Elucidation of interaction between of LINC complex with adhesion molecule

• Project/Area Number: 24659162
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Osaka University
• Principal Investigator: HAMADA Yoshinosuke 大阪大学, 医学(系)研究科(研究院), 助教 (10362683)
• Co-Investigator(Kenkyū-buntansha): MATSUURA Nariaki 大阪大学, 大学院医学系研究科, 教授 (70190402) ; KAWAGUCHI Naomasa 大阪大学, 大学院医学系研究科, 准教授 (70224748) ; MORI Seizi 大阪大学, 大学院医学系研究科, 助教 (90467506)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: LINC complex / nesprin / laminA/C / SUN1 / SUN2 / nesprin2 / 分子病理

Research Abstract

The evaluation of mRNA and protein expression by cellular experiments revealed a decrease in the expression of SUN2 and nesprin 2, and the evaluation of the expression of these proteins by immunostaining of tissue samples revealed a tendency for a decrease in the expression of lamin A/C, SUN1, SUN2, and nesprin 2. Furthermore, results of the statistical analysis showed that lamin A/C and nesprin 2 contributed to the exacerbation of breast cancer. Previous cellular-level studies have also reported the existence of a relationship between decreased lamin A/C expression and the exacerbation of breast cancer. These evidences suggest that the expression of LINC complex proteins tends to be decreased in patients with breast cancer and that a decreased expression of lamin A/C and nesprin 2, in particular, is involved in the exacerbation of breast cancer.

Research Products

• [Journal Article] A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. (2013)
  • Author(s): Mori S, Tran V, Nishikawa K, Kaneda T, Hamada Y, Kawaguchi N, Fujita M, Takada YK, Matsuura N, Zhao M, Takada Y.
  • Journal Title: PLoS One. Volume: 8
  • Peer Reviewed